Metal-organic frameworks (MOFs) have high porosity and surface area, making them ideal candidates for adsorption-mediated applications. One high-value application is the removal of uremic toxins from solution for dialysis. Previous studies have reported adsorptive removal of the uremic toxin -cresyl sulfate from solution via zirconium-based MOFs, but a specific analysis of parameters contributing to adsorptive uptake is needed to clarify differences in uptake performance between MOFs. We synthesized zirconium 1,3,5-benzenetricarboxylate (MOF-808) and an iron-based analog, MIL-100(Fe), and compared their adsorptive uptake with previously reported values of other zirconium-based MOFs. MIL-100(Fe) adsorbed three times more cresyl sulfate from solution on a per mass basis than MOF-808 and had a greater adsorption efficiency than 75% of previously reported Zr-based MOFs. We compared -cresyl sulfate uptake by MOFs as a function of BET surface area, number of aromatic carbons in the organic linker, internal cage diameter, and pore window diameter. There is poor correlation between cresyl sulfate uptake and each of the variables considered, but the number of aromatic carbons of the MOF linker was a better predictor of uptake than BET surface area ( = 0.7034 and 0.1430, respectively), and pore window aperture was a better predictor of uptake than the pore cage diameter ( = 0.4780 and 0.0383, respectively). We hypothesize that the greater adsorptive capacity of MIL-100(Fe) compared to MOF-808 results from direct coordination of cresyl sulfate to vacant metal sites in the MOF, and the total adsorption may be accounted for by some combination of adsorptive interactions occurring at both metal and organic linker sites near to the exterior particle surface. The adsorptive uptake of cresyl sulfate by MIL-100(Fe) was observed to increase with cresyl sulfate content, mass of MIL-100(Fe), and volume of cresyl sulfate solution; the mass of MIL-100(Fe) had the greatest effect on total adsorption.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsami.0c04203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane.
Membranes (Basel)
January 2025
Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
The dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at the blood-membrane interface, aiming to achieve antithrombogenic and antifouling effects. This study aimed to assess the performance and albumin loss of the Hydrolink NV dialyzer in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) with different infusion flows (Qis) and compare it with the hydrophilic FX CorAL dialyzer in post-dilution HDF. A prospective study was carried out in 20 patients.
View Article and Find Full Text PDFTargeted Metabolomics for the Analysis of Cresol in Mouse Brain: Impact of Biological Sex and Strain.
ACS Chem Neurosci
January 2025
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103-287, 41125 Modena, Italy.
-Cresol, an environmental contaminant and endogenous metabolite derived primarily from the conversion of l-tyrosine by intestinal microflora, is gaining increasing attention, due to its potential impact on human health. Recent studies have highlighted elevated levels of -cresol and its metabolites, including -cresyl sulfate and -cresyl glucuronide, in various populations, suggesting a correlation with neurodevelopmental and neurodegenerative conditions. While the role of this compound as a uremic toxin is well established, its presence and concentration within the central nervous system (CNS) remain largely unexplored.
View Article and Find Full Text PDFThe Gut-Kidney Axis in Chronic Kidney Diseases.
Diagnostics (Basel)
December 2024
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
The gut-kidney axis represents the complex interactions between the gut microbiota and kidney, which significantly impact the progression of chronic kidney disease (CKD) and overall patient health. In CKD patients, imbalances in the gut microbiota promote the production of uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, which impair renal function and contribute to systemic inflammation. Mechanisms like endotoxemia, immune activation and oxidative stress worsen renal damage by activating pro-inflammatory and oxidative pathways.
View Article and Find Full Text PDFLiquid chromatography coupled with high resolution mass spectrometry reveals the inhibitory effects of Huangkuisiwu formula on biosynthesis of protein-binding uremic toxins in rats with chronic kidney disease.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Chronic kidney disease (CKD) is recognized as a common disorder worldwide. Protein-binding uremic toxins that cannot be efficiently removed by extracorporeal renal replacement therapies, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are associated with high risks of cardiovascular complications and high mortality in CKD population. This study aimed to explore the therapeutical effects of Huangkuisiwu formula (HKSWF) on CKD rats.
View Article and Find Full Text PDFMetabolomics reveals alterations in gut-derived uremic toxins and tryptophan metabolism in feline chronic kidney disease.
Vet Q
December 2025
Faculty of Veterinary Medicine, Department of Small Animals, Ghent University, Merelbeke, Belgium.
Chronic Kidney Disease (CKD) is one of the most common conditions affecting felines, yet the metabolic alterations underlying its pathophysiology remain poorly understood, hindering progress in identifying biomarkers and therapeutic targets. This study aimed to provide a comprehensive view of metabolic changes in feline CKD across conserved biochemical pathways and evaluate their progression throughout the disease continuum. Using a multi-biomatrix high-throughput metabolomics approach, serum and urine samples from CKD-affected cats ( = 94) and healthy controls ( = 84) were analyzed with ultra-high-performance liquid chromatography-high-resolution mass spectrometry.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!