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TP53 mutations and MDM2 polymorphisms in breast and ovarian cancers: amelioration by drugs and natural compounds.
Clin Transl Oncol
January 2025
Inflammation and Cancer Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam, 784028, India.
Globally, breast and ovarian cancers are major health concerns in women and account for significantly high cancer-related mortality rates. Dysregulations and mutations in genes like TP53, BRCA1/2, KRAS and PTEN increase susceptibility towards cancer. Here, we discuss the impact of mutations in the key regulatory gene, TP53 and polymorphisms in its negative regulator MDM2 which are reported to accelerate cancer progression.
View Article and Find Full Text PDFEvaluating alignment of UK commercial baby food products with the WHO nutrient and promotion profile model.
Eur J Pediatr
January 2025
Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK.
Purpose: The first 1000 days of life are critical for long-term health outcomes, and there is increasing concern about the suitability of commercial food products for infants, toddlers, and children. This study evaluates the compliance of UK commercial baby food products with WHO Nutrient and Promotion Profile Model (NPPM) guidelines.
Methods: Between February and April 2023, data on 469 baby food products marketed for infants and children under 36 months were collected from the online platforms of four major UK supermarkets.
Transosseous Flexor Hallucis Longus Tendon Transfer for Large Achilles Tendon Defects: Surgery Technique and Outcome.
Foot Ankle Int
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Department of Foot Surgery, Schulthess Klinik, Zurich, Switzerland.
Background: Operative management of chronic Achilles tendinopathy with large defects can be surgically challenging. Concerns exist regarding transosseous transfer of the flexor hallucis longus (FHL) tendon because of the shortened lever arm of flexion and weakening of the big toe. The aim of this study was to demonstrate the 2-year outcome of transosseous FHL transfer for the treatment of large Achilles tendon defects.
View Article and Find Full Text PDFExploring Health Sciences Students' Perspectives on Using Generative Artificial Intelligence in Higher Education: A Qualitative Study.
Nurs Health Sci
March 2025
Faculty of Nursing, Nursing Department, Ataturk University, Erzurum, Turkey.
The widespread adoption of artificial intelligence (AI) tools in academic settings has the potential to revolutionize learning experiences, enhance educational outcomes, and streamline academic processes. The aim of this research was to explore the perceptions of Lebanese health sciences students regarding the use of generative AI in higher education. A qualitative descriptive research design informed by descriptive phenomenology was employed.
View Article and Find Full Text PDFLocal Anesthetic Infiltration, Awake Veno-Venous Extracorporeal Membrane Oxygenation, and Airway Management for Resection of a Giant Mediastinal Cyst: A Narrative Review and Case Report.
J Clin Med
December 2024
Anesthesiology and Operative Intensive Care, Faculty of Medicine, University of Augsburg, 86156 Augsburg, Germany.
Mediastinal mass syndrome represents a major threat to respiratory and cardiovascular integrity, with difficult evidence-based risk stratification for interdisciplinary management. We conducted a narrative review concerning risk stratification and difficult airway management of patients presenting with a large mediastinal mass. This is supplemented by a case report illustrating our individual approach for a patient presenting with a subtotal tracheal stenosis due to a large cyst of the thyroid gland.
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