AI Article Synopsis
- Nematode-derived modular metabolites (NDMMs) are small molecules essential for regulating nematodes' development, behavior, and life history, with some functioning as primer pheromones that can cause irreversible changes in development.
- This study analyzed the exo-metabolomes of over 30 nematode species using MS/MS and NMR techniques, revealing 36 new compounds.
- The research indicates that complex NDMMs evolve independently in different nematode lineages and suggests that such biochemical innovation is common across the animal kingdom.
Article Abstract
The small molecules that mediate chemical communication between nematodes-so-called 'nematode-derived-modular-metabolites' (NDMMs)-are of major interest because of their ability to regulate development, behavior, and life-history. nematodes produce an impressive diversity of structurally complex NDMMs, some of which act as primer pheromones that are capable of triggering irreversible developmental switches. Many of these NDMMs have only ever been found in but no attempts have been made to study their evolution by profiling closely related species. This study brings a comparative perspective to the biochemical study of NDMMs through the systematic MS/MS- and NMR-based analysis of exo-metabolomes from over 30 species. We identified 36 novel compounds and found evidence for the convergent evolution of complex NDMMs in separate branches of the phylogeny. Our results demonstrate that biochemical innovation is a recurrent process in nematodes, a pattern that is probably typical across the animal kingdom.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224695 | PMC |
| http://dx.doi.org/10.7554/eLife.55687 | DOI Listing |
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