Purpose: The aims of this study were to determine the test-retest reliability of the duplicated six-minute walk test (6MWT) in patients with chronic heart failure (HF), and to evaluate its variation over time.
Methods: Forty-six patients (9 women) with HF performed duplicated 6MWT every third month for 1 year (5 follow-ups), for a total of 198 paired tests. The patients completed two 6MWT on the same day with a 45-min seated rest between tests.
Results: The mean distance in metres, for the first (6MWT1) versus the second (6MWT2), for each follow-up, was 408 ± 100 versus 411 ± 96, 449 ± 94 versus 465 ± 94, 464 ± 96 versus 473 ± 100, 462 ± 103 versus 468 ± 104 and 472 ± 105 versus 482 ± 107. On average, a marginally, clinically insignificant longer walked distance, 9 m (2.0%), was seen in the second 6MWT. The standard error of a single determination (S ) ranged from 2.4% to 3.9% over the study period, and the intraclass correlation coefficient (ICC) ranged from 0.96 to 0.99 (CI 95% 0.94-0.99). The variation over time of ICC or S was not statistically significant.
Conclusion: The 6MWT is highly reliable over time in patients with HF, and one test is, therefore, sufficient in clinical follow-ups.
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Itching tends to worsen at night in patients with itchy skin diseases, such as atopic dermatitis. Unconscious scratching during sleep can exacerbate symptoms, cause sleep disturbances, or reduce quality of life. Therefore, evaluating nocturnal scratching behaviour is important for better patient care.
View Article and Find Full Text PDFBMC Med Educ
January 2025
School of Health and Life Sciences, University of the West of Scotland, Paisley, Scotland.
Background: Evaluating professional values is crucial to developing effective strategies for integrating them into professional performance and clinical education. A standard questionnaire is an instrument that can be used to evaluate professional values. This study aimed to assess the validity and reliability of the Nurses Professional Values Scale-Revised (NPVS-R) among nursing students in the Persian language.
View Article and Find Full Text PDFTransl Psychiatry
January 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Peripheral inflammatory markers (PIMs), such as C-reactive protein (CRP) or white blood cell count (WBC), have been associated with depression severity in meta-analyses and large cohort studies. However, in typically-sized psychoimmunology studies (N < 200) that explore associations between PIMs and neurobiological/psychosocial constructs related to depression and studies that examine less-studied PIMs (e.g.
View Article and Find Full Text PDFJ Voice
January 2025
Department of Speech and Language Therapy, School of Health Rehabilitation Sciences, University of Patras, Patras, Greece; A' ENT University Clinic, Medical School, National Kapodistreian University of Athens, Athens, Greece. Electronic address:
Objectives: The Singing Voice Handicap Index (SVHI) was culturally adapted and validated in Greek to examine the impacts of voice problems on a singer's everyday life.
Methods: The translated version was administered to 120 singers in total, along with the translated version of the Voice Handicap Index (VHI), a sort voice history questionnaire, two Self-Rating Dysphonia Severity Scales (SRDSSs), and two visual analog scales. A week after the original completion of the Greek version of SVHI, a second copy of the SVHI was administered to 50% of the participants.
Methods Cell Biol
January 2025
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Servei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic Barcelona, Barcelona, Spain; Departament de Biomedicina, Universitat de Barcelona, Barcelona, Spain. Electronic address:
Mice models serve as a valuable tool to study microbiome-immune system interactions. While the use of germ-free mice may represent the gold-standard method, antibiotic-based microbiome depletion provides a more cost-efficient and feasible system. The protocol here in presented provides a mild antimicrobial regime to deplete basal microbiota in 8-week-old C57BL/6 mice, aiming to ensure reproducibility in microbiota studies.
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