AI Article Synopsis
- Postoperative fatigue (POF) is a prevalent issue after gastrointestinal tumor surgeries, negatively impacting patient outcomes and quality of life, and this study aims to identify its risk factors and develop an effective prediction model.
- A prospective study with 598 patients found that factors like age, education level, income, cancer stage, and mental health significantly contribute to the risk of POF.
- Among three prediction models tested, the back-propagation artificial neural networks (BP-ANN) showed the best performance in forecasting POF, suggesting its potential as a noninvasive tool for early risk identification in patients.
Article Abstract
Background: Postoperative fatigue (POF) is a common complication after gastrointestinal tumor surgery, and it also brings negative effect on prognosis and life quality. However, there are no prediction models for POF, and studies of risk factors are not comprehensive. Therefore, the aim of this study is to investigate the risk factors and pick out the best prediction model for POF and to validate it.
Methods: A prospective study was conducted for patients undergoing elective gastrointestinal tumor surgery. Physiological, psychological, and socioeconomic factors were collected. Logistic regression, back-propagation artificial neural networks (BP-ANNs), and classification and regression tree (CART) were constructed and compared.
Results: A total of 598 patients consisting of 463 derivation sample and 135 validation sample were included. The incidence of POF in derivation sample, validation sample, and total were 58.3%, 57.0%, and 58.7%, respectively. Logistic regression results showed age, higher degree of education, lower personal monthly income, advanced cancer, hypoproteinemia, preoperative anxiety or depression, and limited social support were risk factors for POF. Receiver operating characteristic curve (ROC) and performance indices were used to test three models. BP-ANN was the best by the comparison of models, and its strong predictive performance was also validated.
Conclusions: More attention should be paid on specific patients after gastrointestinal tumor surgery. BP-ANN is a powerful mathematical tool that could predict POF exactly. It may be used as a noninvasive screening tool to guide clinicians for early identification of high-risk patients and grading interventions.
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| http://dx.doi.org/10.1007/s00520-020-05483-0 | DOI Listing |
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