Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [Cu]VEGF peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEGFR expression level. Moreover, the tracer showed high tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [Cu]VEGF as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178340 | PMC |
http://dx.doi.org/10.1021/acsomega.9b03953 | DOI Listing |
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