Crocins, enriched in fruits, have a pharmacological activity against central nervous system diseases, cardiovascular diseases, and cancer cell growth. The biosynthesis of crocins has been widely explored, but its regulatory mechanism remains unknown. Here, the basic helix-loop-helix (bHLH) transcription factors related to crocin biosynthesis were systematically identified on the basis of the genome of . A total of 95 transcription factor genes were identified, and their phylogenetic analysis indicated that they could be classified into 23 subfamilies. The combination of gene-specific expression patterns, the coexpression analysis of biosynthesis genes, and the analysis of promoter sequences in crocin biosynthesis pathways suggested that nine in might negatively regulate crocin biosynthesis. This study laid a foundation for understanding the regulatory mechanism of crocin biosynthesis and the improvement and breeding of varieties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165322 | PMC |
| http://dx.doi.org/10.1155/2020/2903861 | DOI Listing |
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Article Synopsis
- Saffron, derived from Crocus sativus flowers, contains crocin, a compound with potential anti-inflammatory and antioxidant effects, although research results have varied.
- A meta-analysis of 13 randomized clinical trials found that crocin supplementation significantly lowered levels of inflammatory markers like CRP, TNF-α, and IL-6 while increasing total antioxidant capacity (TAC).
- The most pronounced effects were observed with doses of 30 mg or more per day over at least 12 weeks, though crocin did not significantly impact erythrocyte sedimentation rate (ESR) or malondialdehyde (MDA) levels.
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