HMG-CoA reductase inhibitors (statins) are one of the most widely used medications in the primary care setting, and like any medications they have many side effects. The common ones include myalgias and rare ones include dermatomyositis. Here we present the case of atorvastatin-induced dermatomyositis with an unfortunate progression. This mandates a low threshold for first contact doctors to screen their patients for new-onset muscle weakness and rash after starting a statin recently, like our patient who had started atorvastatin several months before. This case adds to the previously reported cases and provides further evidence for statins being triggers of immune-mediated disease. The appropriate management of this condition requires a collaborative effort involving clinical judgment, laboratory testing, and imaging.
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http://dx.doi.org/10.7759/cureus.7387 | DOI Listing |
ACG Case Rep J
January 2025
Medstar Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.
Statin-induced liver injury has been widely described. However, cases of clinically significant liver injury are rare. We present a 56-year-old woman who developed atorvastatin-induced grade III acute liver injury with concurrent rhabdomyolysis that worsened after rechallenging, which highlighted the need for pharmacovigilance with statins.
View Article and Find Full Text PDFJ Assoc Physicians India
October 2023
Junior Resident, Department of Geriatric Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Statins are drugs for preventing cardiac events in the elderly population. Statins are well tolerated with a lower reported incidence of serious side effects (<0.15%) like myopathy and elevated transaminases [>3× upper limit of normal (ULN)].
View Article and Find Full Text PDFCureus
March 2024
Internal Medicine, Mayo Hospital, Lahore, PAK.
Acta Dermatovenerol Croat
December 2023
Katarina Trčko, MD, Department of Dermatology and Venereal Diseases, University Medical Centre Maribor, Maribor, Slovenia.; Received: June 21, 2023 Accepted: August 17, 2023.
Lupus erythematosus tumidus (LET) is a rare photosensitive skin disease classified as a separate subtype of cutaneous lupus erythematosus. Clinically, it is characterized by erythematous plaques on sun-exposed areas. Typical histopathological findings are perivascular and periadnexal lymphohistiocytic infiltrates and prominent mucin deposition in the dermis.
View Article and Find Full Text PDFStatins can commonly cause myopathy. Most of the time, stopping the culprit drug should solve the problem. However, if the drug has been discontinued but muscle weakness continues to worsen, immune-mediated myopathy should be taken into consideration.
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