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| http://dx.doi.org/10.1111/j.1745-6606.2005.00010.x | DOI Listing |
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A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countries.
J Dermatolog Treat
December 2025
Sanofi-Evidence Generation and Dissemination Manager Greater Gulf, UAE.
Purpose/aim Of The Study: There is limited real-world evidence regarding the effectiveness and safety of dupilumab in Gulf countries. The study aimed to evaluate atopic dermatitis (AD) disease control in adult and adolescent patients (≥12 years) treated with dupilumab in Gulf countries.
Materials And Methods: This observational study included patients with moderate-to-severe AD who initiated dupilumab within 30 days.
Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2.
JCI Insight
December 2024
Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, California, USA.
T cells are involved in protective immunity against numerous viral infections. Data regarding functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID-19 are limited. To address this knowledge gap, we assessed samples for associations between SARS2 upper respiratory tract viral RNA levels and early virus-specific adaptive immune responses for 95 unvaccinated clinical trial participants with acute primary COVID-19 aged 18-86 years old, approximately half of whom were considered at high risk for progression to severe COVID-19.
View Article and Find Full Text PDFFlying with nut and other food allergies: unravelling fact from fiction.
Arch Dis Child
December 2024
Aviation Medical Consultancy Limited, Burgess Hill, UK.
There is a common perception that peanut/tree nut particles can be transmitted through aircraft ventilation systems and pose a significant risk to passengers with food allergies. In fact, food-induced allergic reactions are around 10-100 times less common during flights than 'on the ground', perhaps because of the multiple precautions food-allergic passengers take when flying. We review the evidence for strategies to help prevent accidental allergic reactions while travelling on commercial flights (review registered at PROSPERO, ref CRD42022384341).
View Article and Find Full Text PDFGerminal center B-cell subgroups in the tumor microenvironment cannot be overlooked: Their involvement in prognosis, immunotherapy response, and treatment resistance in head and neck squamous carcinoma.
Heliyon
October 2024
Department of Stomatology, the First Affiliated Hospital of Soochow University, 188 Shi Zi Rd, Suzhou, 215006, China.
Article Synopsis
- * This study utilized single-cell RNA sequencing (scRNA-seq) to analyze HNSCC tissues and blood samples, identifying four B-cell subgroups and their roles in tumor interactions, while also developing a prognostic risk model based on clinical features and immune responses.
- * The findings introduced germinal center B cells (GCBs) as new prognostic biomarkers for HNSCC, with the MEF2B GCB score providing insights for potential therapeutic targets and improving genetic prognosis in HNSCC patients.
An Effective Treatment for Recurrent Bilateral Facial Palsy in a Flight Attendant: A Case Report.
Cureus
February 2024
Otolaryngology - Head and Neck Surgery, Queen Elizabeth Hospital, Kota Kinabalu, MYS.
Recurrent facial baroparesis is a rare condition that is mostly observed in individuals who have been exposed to barotraumatic conditions, particularly scuba divers and air travelers. We present a case of an unusual bilateral alternating recurrent facial nerve palsy and its successful treatment. A 34-year-old airline stewardess presented with a seven-month history of recurrent bilateral alternating facial nerve palsy that occurred exclusively during airline takeoffs.
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