The mouse bioassay for tetrodotoxin has been used in Japan and ddY strain mice are designated to be used in the assay. ddY strain is a closed-colony outbred mouse strain, originally from the National Institute of Health, however, the ddY mouse stocks of 3 breeders were divided 30 or more years ago. In this study, we investigated the differences in susceptibility to tetrodotoxin in ddY strain mice from 3 different breeders in Japan. No statistically significant differences were found among the ddY strain mice of 3 breeders, however, the coefficient of variation were different among the breeders. The results using the mice from one breeder were much stable compared with those using the mice from other 2 breeders.
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