AI Article Synopsis
- Neurotensin, discovered in 1973, has important roles in both hormones and brain function, influencing cancer cell behavior through its three main receptors.
- The effects of neurotensin are mediated by various signaling pathways, including mitogen-activated protein kinases and phosphatidylinositol-3 kinases, which are crucial in cancer progression.
- Understanding neurotensin's molecular mechanisms in cancers could lead to the development of targeted therapies and personalized treatment strategies.
Article Abstract
Background: Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of cancers. Expression of Neurotensin and its receptors has also been correlated to prognosis and prediction to treatment.
Main Body: The effects of NT are mediated through mitogen-activated protein kinases, epidermal growth factor receptors and phosphatidylinositol-3 kinases amongst others. This review is a comprehensive summary of the molecular pathways by which Neurotensin and its receptors act in cancer cells.
Conclusion: Identifying the role of Neurotensin in the underlying molecular mechanisms in various cancers can give way to developing new agnostic drugs and personalizing treatment according to the genomic structure of various cancers. Video abstract.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183616 | PMC |
| http://dx.doi.org/10.1186/s12964-020-00569-y | DOI Listing |
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