AI Article Synopsis
- The study assessed the effectiveness of a therapeutic approach using antimicrobial photodynamic therapy (aPDT) with 450 nm blue LED and curcumin in AIDS patients.
- The research involved collecting saliva samples from patients both before and after treatment, showing a significant reduction in harmful microorganisms post-therapy.
- Results indicated that aPDT successfully controlled key intraoral microbes in patients irrespective of their TCD4 and TCD8 lymphocyte levels.
Article Abstract
Objectives: To test the effectiveness of an efficient therapeutic protocol for the total mouth antimicrobial photodynamic therapy (aPDT) mediated by 450 nm blue LED associated with curcumin in individuals with AIDS.
Methods: Patients were selected by exclusion criteria and randomly distributed in groups to test the effectiveness of antimicrobial aPDT with curcumin 0.75 mg/mL associated with the blue LED (67 mW/cm, 20.1 J/cm). Before and after the treatments, samples were collected from the saliva being processed in duplicate in selective culture media. The colonies were counted and the results obtained in log10 CFU/mL were statistically tested (T-paired statistical test, 5%).
Results: The log10 CFU/mL of spp., spp., and total count of microorganisms showed statistically significant (p = 0.023; p = 0.001 and p = 0.017, respectively) reduction after treatment in patients with aPDT.
Conclusion: aPDT was effective in reducing spp. in addition to reducing spp., enterobacteria and the total count of microorganisms when considering the numbers of TCD4 and TCD8 lymphocytes. The aPDT in the studied protocol was able to control clinically important intraoral microorganisms for AIDS patients, both those with TCD4 lymphocytes above or below 25% of normal and those with TCD8 lymphocytes above 25% of normal.
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| http://dx.doi.org/10.1080/14787210.2020.1756774 | DOI Listing |
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