Hyperthyroidism may cause cognitive decline and increases the risk of Alzheimer's disease (AD), the major form of dementia; however, the underlying mechanism of this relationship is unclear. AD is associated with increased serum levels of tau. In this study, we investigated the relationship between serum thyroid hormones (THs) and tau. Fifty participants diagnosed with hyperthyroidism and fifty euthyroid counterparts were included and received clinical examinations. Serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and tau protein were assessed. The total tau protein level was significantly higher in hyperthyroidism participants than in their euthyroid counterparts. The level of circulating total tau had a significant positive association with the serum concentrations of FT3 and FT4. Total tau level was increased in the low TSH group and the serum THs decreased with the increase of age. These findings reveal that peripheral THs are associated with the serum concentration of tau, which may be involved in the pathogenesis of AD, suggesting a potential therapeutic target of AD via hyperthyroidism therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2020.135003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biased attention allocation in major depressive disorder: A replication and exploration of the potential effects of depression history.
J Affect Disord
January 2025
School of Psychological Sciences, Tel Aviv University, Tel-Aviv, Israel. Electronic address:
Background: Increased attention allocation to negative-valenced information and decreased attention allocation to positive-valenced information have been implicated in the etiology and maintenance of depression. The Matrix task, a free-viewing eye-tracking attention assessment task, has shown corroborating results, coupled with adequate reliability. Yet, replication efforts are still needed.
View Article and Find Full Text PDFCognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure.
Alzheimers Dement
January 2025
Department of Neuroscience, University of California, Berkeley, California, USA.
Introduction: Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear.
Methods: A total of 109 cognitively normal older adults (70+ years old) underwent amyloid beta (Aβ) and tau positron emission tomography (PET) imaging, structural magnetic resonance imaging (MRI), and cognitive testing. Cognitive aging was quantified using the cognitive age gap (CAG), subtracting chronological age from predicted cognitive age.
On Your Mark, Get Set, Choose! A Randomized Cross-Over Study Comparing Fixed and Self-Selected Rest Periods in Interval Running Among Professional Female Soccer Players.
Sports Med Open
January 2025
Department of Health Promotion, Faculty of Medical and Health Sciences, School of Public Health, Tel-Aviv University, Tel-Aviv, Israel.
Background: Studies on rest durations during high-intensity interval training (HIIT) often compare fixed and self-selected (SS) rest allocation approaches. Frequently, the rest duration under SS conditions is unlimited, leading to inconsistent total rest durations compared to fixed rest conditions. To address this limitation, we recently compared fixed and SS rest conditions during cycling HIIT sessions, while keeping the total rest duration equivalent.
View Article and Find Full Text PDFSecondary bile acid derivatives are contributors to the fecal bile acid pool and associated with bile acid modulating nutrients.
J Nutr
January 2025
Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA; University of Illinois Cancer Center, Chicago, Illinois, USA. Electronic address:
Objective: Accumulation of hydrophobic bile acids is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic bile acids. The impact of diet on secondary bile acid (BA) derivative production has not been determined.
View Article and Find Full Text PDFA Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects.
Drug Des Devel Ther
January 2025
School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.
Background: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.
Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.
Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!