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The prebiotic potential of lactobin and glucans combined with goat's milk in cats.
Can J Vet Res
January 2025
Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, No. 12 Zhong Guan Cun South Street, Haidian District, Beijing 100081, China (Han, Sun, Gu, J. Wang, X. Wang, Tao, Z. Wang, Liu); Jiangxi Agricultural University, No. 1225, Zhimin Avenue, Xinjian District, Nanchang City 330045, China (Gu).
Prebiotics are important for gut health and immunity in animals and could promote the growth of beneficial bacteria. The objective of this study was to investigate the prebiotic potential of lactobin and glucans when combined with goat's milk in the diet of cats. Twenty-four healthy cats (all about 2 y old) were randomly assigned to 4 treatment groups.
View Article and Find Full Text PDFHypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis.
Front Endocrinol (Lausanne)
January 2025
Celvia CC AS, Tartu, Estonia.
Background: Endometriosis is characterized by the ectopic growth of endometrial-like cells, causing chronic pelvic pain, adhesions and impaired fertility in women of reproductive age. Usually, these lesions grow in the peritoneal cavity in a hypoxic environment. Hypoxia is known to affect gene expression and protein kinase (PK) activity.
View Article and Find Full Text PDFPhospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of .
mLife
December 2024
State Key Laboratory of Mycology, Institute of Microbiology Chinese Academy of Sciences Beijing China.
Glycosylphosphatidylinositol (GPI) anchoring is one of the conserved posttranslational modifications in eukaryotes that attach proteins to the plasma membrane. In fungi, in addition to plasma membrane GPI-anchored proteins (GPI-APs), some GPI-APs are specifically released from the cell membrane, secreted into the cell wall, and covalently linked to cell wall glucans as GPI-anchored cell wall proteins (GPI-CWPs). However, it remains unclear how fungal cells specifically release GPI-CWPs from their membranes.
View Article and Find Full Text PDFEnhanced Insulin Production From Porcine Islets: More Insulin, Less Islets.
Transpl Int
January 2025
Pôle de Chirurgie Expérimentale et Transplantation, Université Catholique de Louvain, Brussels, Belgium.
Clinical pancreatic islet xenotransplantation will most probably rely on genetically modified pigs as donors. Several lines of transgenic pigs carrying one and more often, multiple modifications already exist. The vast majority of these modifications aim to mitigate the host immune response by suppressing major xeno-antigens, or expressing immunomodulatory molecules that act locally at the graft site.
View Article and Find Full Text PDFPersistence and/or Senescence: Not So Lasting at Last?
Cancer Res
January 2025
Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum - MKFZ, Campus Virchow Klinikum, Charité - Universitätsmedizin, Berlin, Germany.
Therapy-exposed surviving cancer cells may have encountered profound epigenetic remodeling that renders these drug-tolerant persisters candidate drivers of particularly aggressive relapses. Typically presenting as slow-to-nongrowing cells, persisters are senescent or senescence-like cells. In this issue of Cancer Research, Ramponi and colleagues study mTOR/PI3K inhibitor-induced embryonic diapause-like arrest (DLA) as a model of persistence in lung cancer and melanoma cells and compare this persister condition with therapy-induced senescence in the same cells.
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