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Molecular Mechanisms of Nicergoline from Ergot Fungus in Blocking Human 5-HT3A Receptor.
J Microbiol Biotechnol
November 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju 61186, Republic of Korea.
This study investigates the modulatory effects of nicergoline, a major bioactive compound derived from ergot fungus, on the 5-hydroxytryptamine 3A (5-HT3A) receptor. Utilizing a two-electrode voltage-clamp technique, we evaluated the impact of nicergoline on the 5-HT-induced inward current (I) in 5-HT3A receptors. Our findings reveal that nicergoline inhibits I in a reversible and concentration-dependent manner.
View Article and Find Full Text PDFOptical coherence tomography-enabled classification of the human venoatrial junction.
J Biomed Opt
January 2025
Columbia University, Department of Electrical Engineering, New York, United States.
Significance: Radiofrequency ablation to treat atrial fibrillation (AF) involves isolating the pulmonary vein from the left atria to prevent AF from occurring. However, creating ablation lesions within the pulmonary veins can cause adverse complications.
Aim: We propose automated classification algorithms to classify optical coherence tomography (OCT) volumes of human venoatrial junctions.
Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cells.
Sci Rep
January 2025
Department of Physiology and Neurobiology, Institute of Biology, Eötvös Loránd University, Pázmány Péter Sétány 1/C, Budapest, 1117, Hungary.
Neurons derived from induced pluripotent stem cells (h-iPSC-Ns) provide an invaluable model for studying the physiological aspects of human neuronal development under healthy and pathological conditions. However, multiple studies have demonstrated that h-iPSC-Ns exhibit a high degree of functional and epigenetic diversity. Due to the imprecise characterization and significant variation among the currently available maturation protocols, it is essential to establish a set of criteria to standardize models and accurately characterize and define the developmental properties of human neurons derived from iPSCs.
View Article and Find Full Text PDFPEDRA-EFB0: colorectal cancer prognostication using deep learning with patch embeddings and dual residual attention.
Med Biol Eng Comput
January 2025
Radiol Dept, Jiangnan Univ, Affiliated Hosp, Wuxi, 214122, Jiangsu, People's Republic of China.
In computer-aided diagnosis systems, precise feature extraction from CT scans of colorectal cancer using deep learning is essential for effective prognosis. However, existing convolutional neural networks struggle to capture long-range dependencies and contextual information, resulting in incomplete CT feature extraction. To address this, the PEDRA-EFB0 architecture integrates patch embeddings and a dual residual attention mechanism for enhanced feature extraction and survival prediction in colorectal cancer CT scans.
View Article and Find Full Text PDFRare but important gastrointestinal complications after laparoscopic inguinal hernia repair: a single-center experience.
Sci Rep
January 2025
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No. 99, Longcheng Street, Xiaodian District, Taiyuan, 030032, Shanxi Province, China.
Transabdominal preperitoneal patch plasty (TAPP) versus total extraperitoneal patch plasty (TEP) are surgical techniques commonly used to treat inguinal hernia. However, studies indicate that both procedures may lead to significant complications, particularly gastrointestinal complications, some of which can be life-threatening. We statistically analyzed the complications caused by adult inguinal hernia patients admitted from 2018 to 2022.
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