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Alzheimers Dement
December 2024
University of Helsinki, Helsinki, Uusimaa, Finland.
Background: When treatments against neurodegenerative diseases eventuate, the most successful time point to administer therapies will be the early stages, most likely before symptoms begin to show. Previous studies have found alpha-synuclein pathology (Lewy-related pathology; LRP) in asymptomatic individuals aged 62 years and above, with ranges from 8 to 17%.
Method: We performed immunohistochemical staining with the 5G4 antibody against alpha-synuclein on brain tissue samples from the Tampere Sudden Death Study - a collection of forensic autopsies on individuals that lived outside hospital institutions in Tampere and the surrounding regions, Finland.
Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.
BMC Med
January 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable cognitive boundaries to differentiate the subgroups remain elusive. The key challenge for cognitive subtyping is applying an integrated and standardized cognitive assessment and understanding the subgroup-specific neurobiological mechanisms.
View Article and Find Full Text PDFInjury Patterns and Associated Demographic Characteristics in Children with a Fracture from Equines: A US National Based Study.
Children (Basel)
November 2024
Department of Orthopaedic Surgery, George Washington University School of Medicine, Washington, DC 20052, USA.
Background: Fractures often occur due to equestrian activities with injury patterns varying by age. The purpose of this study was to investigate in detail fracture patterns and associated demographics in children due to equine activities.
Materials: The US National Electronic Injury Surveillance System was queried for all injuries with the consumer product code 1239 (horseback riding) from 2000 to 2023.
Attributes Desired in a General Practitioner by Adults: Implications for Humanization in Medicine and Enhancement of the Patient Experience.
Healthcare (Basel)
December 2024
Department of Economic Psychology, Kozminski University, 03-301 Warszawa, Poland.
Background: Progress in medical education is reflected in healthcare quality and patient satisfaction. However, there are still gaps in knowledge regarding the patients' expectations of general practitioners (GPs), even though patients' interactions with GPs are among the most frequent in healthcare. Accordingly, this study investigated the qualities desired by adults in GPs, intending to include them in future medical humanization education to enhance the patients' experience.
View Article and Find Full Text PDFEquity and the operational considerations of the kidney transplant allocation system.
Curr Opin Organ Transplant
January 2025
Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons.
Purpose Of Review: Demonstrate the impact of allocation system design on access to the waitlist and transplantation for patients with end-stage kidney disease (ESKD).
Recent Findings: Minoritized groups are more likely to be declined from transplant listing owing to psychosocial criteria. Lack of consistent definitions, screening tools with differential subgroup validity, and insufficient evidence-base contribute to concerns about reliance on psychosocial factors in transplant listing decisions.
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