During the course of the more than 2000 years of its recorded history, delirium has been given a very large number of different names, including phrenitis and paraphrenitis, mania and délire maniaque, (febrile, agitated, asthenic, lethargic, reversible toxic, symptomatic, exogenous) psychosis, inattention, acute and reversible dementia and insanity, amentia and sensorial phrenosis, reversible cognitive dysfunction, paralepsia, confusion and mental confusion, disorientation, dysergasia, and incoherence. Such a wide range of names with related definitions and pathogenic hypotheses not only bears witness to the interest that delirium has aroused in clinical investigators, but also reflects the difficulties in scientifically investigating its intrinsic nature. Furthermore, these difficulties have raised doubts about making a diagnosis that may explain why its incidence is reported to be under-estimated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10072-020-04438-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accumulating the key proteomic signatures associated with delirium: Evidence from systematic review.
PLoS One
December 2024
NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Article Synopsis
- Delirium is a serious neuropsychiatric condition seen often in intensive care and post-surgery, leading to longer hospital stays and higher mortality/morbidity rates.
- A systematic review analyzed 1746 studies on delirium biomarkers from 2000-2023, resulting in the inclusion of 78 studies emphasizing proteomic signatures related to the condition.
- The review identified 313 proteins, with a focus on 13 key proteins (like IL-6, CRP, and TNF-a) that show a significant link to delirium, highlighting the need for more research to better understand these biomarkers for diagnosis and treatment.
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications.
BMC Geriatr
August 2024
Bioinformatics Lab, Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Background: Delirium and Alzheimer's disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia.
View Article and Find Full Text PDFChronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges.
Ann Intensive Care
July 2022
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, 94143, USA.
Article Synopsis
- Post-intensive care syndrome (PICS) is a condition that causes lasting physical, cognitive, and mental impairments after leaving the ICU, significantly affecting patients' long-term health and quality of life.
- The review discusses key issues related to PICS, including muscle weakness, cognitive deficits associated with delirium, and long-term effects on the immune system, kidneys, and lungs.
- Understanding the biological processes underlying PICS can lead to improved patient care and new strategies for prevention and treatment.
Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients.
Front Aging Neurosci
May 2021
Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Delirium is a common serious complication that often occurs after major surgery. The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and mRNAs in patients of postoperative delirium (POD). Microarray analysis was performed on the peripheral blood samples to identify differentially expressed (DE) lncRNAs and mRNAs in 4 POD patients and 4 non-POD volunteers.
View Article and Find Full Text PDFDeciphering delirium through semantics: a selective synopsis.
Neurol Sci
May 2021
Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, I-20133, Milan, Italy.
During the course of the more than 2000 years of its recorded history, delirium has been given a very large number of different names, including phrenitis and paraphrenitis, mania and délire maniaque, (febrile, agitated, asthenic, lethargic, reversible toxic, symptomatic, exogenous) psychosis, inattention, acute and reversible dementia and insanity, amentia and sensorial phrenosis, reversible cognitive dysfunction, paralepsia, confusion and mental confusion, disorientation, dysergasia, and incoherence. Such a wide range of names with related definitions and pathogenic hypotheses not only bears witness to the interest that delirium has aroused in clinical investigators, but also reflects the difficulties in scientifically investigating its intrinsic nature. Furthermore, these difficulties have raised doubts about making a diagnosis that may explain why its incidence is reported to be under-estimated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!