Antibacterial Activities of Novel Dithiocarbamate-Containing 4-Chromen-4-one Derivatives.

To aid the development of novel antibacterial agents that possess a innovative mechanism of action, we built a series of novel dithiocarbamate-containing 4-chromen-4-one derivatives. We evaluated the activities of the derivatives against three plant pathogens pv ( pv .), (), and pv ( pv .). The results of the antibacterial bioassay showed that most of the target compounds displayed good inhibitory effects against pv . and pv . Remarkably, compound showed the best antibacterial activity against pv ., with an EC value of 0.11 μg/mL, which was better than those of thiodiazole copper (59.97 μg/mL) and bismerthiazol (48.93 μg/mL). Compound exhibited the best antibacterial activity against pv , with an EC value of 1.58 μg/mL, which was better than those of thiodiazole copper (83.04 μg/mL) and bismerthiazol (56.05 μg/mL). Scanning electron microscopy analysis demonstrated that compounds and caused the rupture or deformation of the cell membranes for pv . and pv , respectively. antibacterial activity test and the defensive enzymes activity test results indicated that the compound could reduce pv . more effectively than thiodiazole-copper or bismerthiazol.