AI Article Synopsis
- The combination of Pd(TFA) and pyridine-hydrazone ligands serves as effective catalysts for the asymmetric addition of aryl boronic acids to specific hydrazone compounds.
- These reactions produce α-aryl α-hydrazino esters and amides with high levels of enantioselectivity.
- After removing the carbamoyl group, this process yields important building blocks for developing hydrazinopeptides, N-aminopeptides, and similar compounds.
Article Abstract
Catalysts generated by combinations of Pd(TFA) and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding α-aryl α-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides, N-aminopeptides and peptidomimetics thereof.
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| http://dx.doi.org/10.1039/d0cc02478c | DOI Listing |
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