A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia.

J Alzheimers Dis Rep

Department of Neurology, Agano City Hospital, Niigata, Japan.

Published: March 2020

A 69-year-old right-handed woman developed difficulty naming objects and word-finding. The clinical features of language disorder and predominant atrophy on MRI and predominant hypoperfusion on I-IMP SPECT in the left temporo-parietal junction area were consistent with the diagnostic criteria for the logopenic variant of primary progressive aphasia (lvPPA). Neurological examination showed slight right-side rigidity and resting tremor (UPDRS-III: 4). I-FP-CIT SPECT showed presynaptic dopamine transporter reduction in the posterior putamina with left-side predominance. The odor-stick identification test for Japanese exhibited complete loss of the sense of smell (anosmia). These findings suggest that lvPPA may be accompanied by parkinsonism and anosmia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175926PMC
http://dx.doi.org/10.3233/ADR-190158DOI Listing

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