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The role of agriculture in Nepal's economic development: Challenges, opportunities, and pathways for modernization.
Heliyon
January 2025
Institute of Agriculture and Animal Science, Tribhuvan University, Nepal.
Nepal's economy is primarily dependent on agriculture, which generates a significant amount of GDP and jobs, particularly in rural areas. Despite its importance, the business still faces challenges from low productivity, traditional methods, inadequate access to advanced technologies, and increasing climate change sensitivity. These problems prevent agriculture from realizing its full potential to advance economic development, reduce poverty, and provide food security.
View Article and Find Full Text PDFIntraindividual Comparison of Image Quality Between Low-Dose and Ultra-Low-Dose Abdominal CT With Deep Learning Reconstruction and Standard-Dose Abdominal CT Using Dual-Split Scan.
Invest Radiol
January 2025
From the Department of Radiology, Ulsan University Hospital, Ulsan, Republic of Korea (T.Y.L.); Department of Radiology, University of Ulsan College of Medicine, Seoul, Republic of Korea (T.Y.L.); Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea (J.H.Y., H.K., J.M.L.); Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea (J.H.Y., S.H.P., J.M.L.); Department of Radiology, Inje University Busan Paik Hospital, Busan, Republic of Korea (J.Y.P.); Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (S.H.P.); Department of Radiology, Hanyang University College of Medicine, Seoul, Republic of Korea (C.L.); Division of Biostatistics, Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea (Y.C.); and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea (J.M.L.).
Objective: The aim of this study was to intraindividually compare the conspicuity of focal liver lesions (FLLs) between low- and ultra-low-dose computed tomography (CT) with deep learning reconstruction (DLR) and standard-dose CT with model-based iterative reconstruction (MBIR) from a single CT using dual-split scan in patients with suspected liver metastasis via a noninferiority design.
Materials And Methods: This prospective study enrolled participants who met the eligibility criteria at 2 tertiary hospitals in South Korea from June 2022 to January 2023. The criteria included (a) being aged between 20 and 85 years and (b) having suspected or known liver metastases.
SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression.
Invest Ophthalmol Vis Sci
January 2025
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang, China.
Purpose: This study aimed to investigate the role of SIRT4 in retinal protection, specifically its ability to mitigate excitotoxic damage to Müller glial cells through the regulation of mitochondrial dynamics and glutamate transporters (GLASTs).
Methods: A model of retinal excitatory neurotoxicity was established in mice. Proteins related to mitochondrial dynamics, GLAST, and SIRT4 were analyzed on days 0, 1, 3, and 5 following toxic injury.
Addressing residual and recurrent aneurysms post-Woven EndoBridge device embolization: a systematic review and meta-analysis.
J Neurointerv Surg
January 2025
Department of Neurosurgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA
Background: Early literature on the Woven EndoBridge (WEB) device reported 80-90% adequate aneurysm occlusion but low complete occlusion (40-55%). It is uncertain whether residual or recurrent aneurysms require re-treatment to prevent future rupture.
Objective: To systematically review the literature to meta-analyze occlusion and complication rates after re-treatment of these aneurysms.
Small molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells.
J Clin Invest
January 2025
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, United States of America.
Dysregulated eIF4E-dependent translation is a central driver of tumorigenesis and therapy resistance. eIF4E binding proteins (4E-BP1/2/3) are major negative regulators of eIF4E-dependent translation that are inactivated in tumors through inhibitory phosphorylation or downregulation. Previous studies have linked PP2A phosphatase(s) to activation of 4E-BP1.
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