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Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men. | LitMetric

Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men.

Nutrients

Laboratory of Exercise Biochemistry, University of Taipei, No.101, Sec. 2, Zhongcheng Road., Shilin District, Taipei City 11153, Taiwan.

Published: April 2020

AI Article Synopsis

  • - The study investigated the effects of anserine, found in chicken essence, on exercise-related oxidative stress and cell health by having ten healthy young men consume low or high doses of anserine or a placebo after a strenuous workout.
  • - Results showed that anserine significantly increased antioxidant activity (SOD) and preserved catalase function, but also raised the levels of oxidative stress markers (GSSG), lowering the GSH/GSSG ratio without major impacts on cell damage markers like GOT and myoglobin.
  • - While haematological parameters remained mostly unchanged, the high dose of anserine led to increased mean cell volume (MCV) and decreased mean corpuscular hemoglobin concentration (MCHC), suggesting

Article Abstract

The study tested whether anserine (beta-alanyl-3-methyl-l-histidine), the active ingredient of chicken essence affects exercise-induced oxidative stress, cell integrity, and haematology biomarkers. In a randomized placebo-controlled repeated-measures design, ten healthy men ingested anserine in either a low dose (ANS-LD) 15 mg.kg.bw, high dose (ANS-HD) 30 mg.kg.bw, or placebo (PLA), following an exercise challenge (time to exhaustion), on three separate occasions. Anserine supplementation increased superoxide dismutase (SOD) by 50% ( < 0.001, effect size d = 0.8 for both ANS-LD and ANS-HD), and preserved catalase (CAT) activity suggesting an improved antioxidant activity. However, both ANS-LD and ANS-HD elevated glutathione disulfide (GSSG), (both < 0.001, main treatment effect), and consequently lowered the glutathione to glutathione disulfide (GSH/GSSG) ratio compared with PLA ( < 0.01, main treatment effect), without significant effects on thiobarbituric acid active reactive substances (TBARS). Exercise-induced cell damage biomarkers of glutamic-oxaloacetic transaminase (GOT) and myoglobin were unaffected by anserine. There were slight but significant elevations in glutamate pyruvate transaminase (GPT) and creatine kinase isoenzyme (CKMB), especially in ANS-HD ( < 0.05) compared with ANS-LD or PLA. Haematological biomarkers were largely unaffected by anserine, its dose, and without interaction with post exercise time-course. However, compared with ANS-LD and PLA, ANS-HD increased the mean cell volume (MCV), and decreased the mean corpuscular haemoglobin concentration (MCHC) ( < 0.001). Anserine preserves cellular homoeostasis through enhanced antioxidant activity and protects cell integrity in healthy men, which is important for chronic disease prevention. However, anserine temporal elevated exercise-induced cell-damage, together with enhanced antioxidant activity and haematological responses suggest an augmented exercise-induced adaptative response and recovery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231017PMC
http://dx.doi.org/10.3390/nu12041146DOI Listing

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