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Differential expression of the long and truncated Hv1 isoforms in breast-cancer cells. | LitMetric

Differential expression of the long and truncated Hv1 isoforms in breast-cancer cells.

J Cell Physiol

Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET-UNLP, La Plata, Buenos Aires, Argentina.

Published: November 2020

AI Article Synopsis

Article Abstract

Metabolic reprogramming of cancer cells results in a high production of acidic substances that must be extruded to maintain tumor-cell viability. The voltage-gated proton channel (Hv1) mediates highly selective effluxes of hydronium-ion (H ) that prevent deleterious cytoplasmic acidification. In the work described here, we demonstrated for the first time that the amino-terminal-truncated isoform of Hv1 is more highly expressed in tumorigenic breast-cancer-cell lines than in nontumorigenic breast cells. With respect to Hv1 function, we observed that pharmacologic inhibition of that channel, mediated by the specific blocker 5-chloro-2-guanidinobenzimidazole, produced a drop in intracellular pH and a decrease in cell viability, both in monolayer and in three-dimensional cultures, and adversely affected the cell-cycle in tumorigenic breast cells without altering the cycling of nontumorigenic cells. In conclusion, our results demonstrated that the Hv1 channel could be a potential tool both as a biomarker and as a therapeutic target in breast-cancer disease.

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Source
http://dx.doi.org/10.1002/jcp.29719DOI Listing

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