AI Article Synopsis
- Piperacillin/tazobactam (TZP) is used to treat severe multi-resistant infections but can cause complications like thrombocytopenia, a condition of low platelet count.
- A 73-year-old man developed serious bleeding issues, including lung hemorrhage and diarrhea, despite having normal platelet counts and coagulation tests, indicating a rare case of platelet dysfunction caused by TZP.
- This case highlights that TZP can induce bleeding through mechanisms other than thrombocytopenia, emphasizing the importance of platelet functional tests for proper diagnosis.
Article Abstract
Objective: Piperacillin/tazobactam (TZP ) is commonly used against multi-resistant nosocomial infections. While TZP-induced thrombocytopenia is a well-known and easily diagnosed complication, we herein present an unusual case of spontaneous TZP-induced bleeding caused by platelet dysfunction.
Case Summary: A 73-year-old-man experienced severe pulmonary hemorrhage and bloody diarrhea during the treatment with TZP for ventilator-associated pneumonia. While both platelet count and coagulation tests were normal, platelet functional test revealed severely impaired ADP-dependent platelet aggregation.
Conclusion: Platelet dysfunction is a little-known mechanism of TZP-induced bleeding. This is the second reported case of TZP-related bleeding that has been attributed to platelet dysfunction, and the first case report that has not been associated with surgery. While thrombocytopenia is easily recognized, this form of TZP-induced bleeding can be detected only by platelet functional tests.
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| http://dx.doi.org/10.5414/CP203721 | DOI Listing |
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Severe bleeding caused by piperacillin/tazobactam-induced platelet dysfunction .
Int J Clin Pharmacol Ther
August 2020
Article Synopsis
- Piperacillin/tazobactam (TZP) is used to treat severe multi-resistant infections but can cause complications like thrombocytopenia, a condition of low platelet count.
- A 73-year-old man developed serious bleeding issues, including lung hemorrhage and diarrhea, despite having normal platelet counts and coagulation tests, indicating a rare case of platelet dysfunction caused by TZP.
- This case highlights that TZP can induce bleeding through mechanisms other than thrombocytopenia, emphasizing the importance of platelet functional tests for proper diagnosis.
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