Background: The active butanol detection thresholds (B-DT), determined using the sniffin' sticks, show a high intra- and inter-individual test-retest reliability, although the internal stimulus concentration may vary considerably depending on the dilution of the external stimulus concentration with odorless ambient air during active sniffing. There are various hypotheses for this surprising result. In this study, it should be tested whether a larger respiratory effort (vigor) under physical stress changes the active B-DT.
Methods: In 28 young, healthy, normosmic adults, sitting on a stationary bicycle ergometer at rest phase, during aerobic exercise and in the recovery phase, the monorhinal B-DT using Sniffin' Sticks were determined. Various vital parameters such as blood pressure, heart frequency, body temperature, respiratory frequency and blood lactate characterized the three test phases. The individual stress perception was estimated according to the Borg scale.
Results: The B-DT did not change in the three test phases. All examined vital parameters were significantly larger in the loading phase than in the resting phase. In the case of a moderate to severe stress sensation (Borg-scale: 13-15), an aerobic physical stress could be confirmed on the basis of the vital parameters.
Conclusions: The investigations support the hypothesis that vigor is not the decisive factor for a constant olfactory perception of external equal stimulus concentrations. The integration of internal stimulus concentration and nasal flow velocity and the empirical evaluation of the current odor concentration probably play a greater role.
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http://dx.doi.org/10.1055/a-1151-4912 | DOI Listing |
Front Neurosci
January 2025
Kontigo Care AB, Uppsala, Sweden.
Background: It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.
Methods: In this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18-70 years old, all with informed consent, 12 subjects per drug).
Biochim Biophys Acta Biomembr
January 2025
Faculty of Veterinary Medicine, University of Calgary, Canada. Electronic address:
The intestinal barrier, held together by epithelial cells and intercellular tight junction (TJ) proteins, prevents the penetration of microbial pathogens. Concurrently, intestinal epithelial cells secrete antimicrobial peptides, including cathelicidin. Cathelicidin has direct antibacterial and immunomodulatory functions, although its role in intestinal integrity remains elusive.
View Article and Find Full Text PDFJ Anim Sci Biotechnol
January 2025
Center for Animal Nutrition and Welfare, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria.
Background: The objective was to characterize the colostrum proteome of primiparous Holstein cows in association with immunoglobulin G (IgG) content. Immediately after calving, colostrum samples were collected from 18 cows to measure IgG concentration. Based on colostrum IgG content, samples were classified through cluster analysis and were identified as poor, average, and excellent quality.
View Article and Find Full Text PDFEur J Clin Invest
January 2025
Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
Background: Steroid hormones are key mediators of adaptative responses to exercise, a stimulus that may concurrently affect their blood concentrations. However, the chronic endocrine adaptations and whether these potential changes are dependent on exercise intensity remain undetermined. Moreover, it is also unknown if the exercise-induced effects on steroid hormonal status are related to the participant' sex.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a form of dementia in which memory and cognitive decline is thought to arise from underlying neurodegeneration. These cognitive impairments, however, are transient when they first appear and can fluctuate across disease progression. Here, we investigate the neural mechanisms underlying fluctuations of performance in amnestic mice.
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