P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa.

Cell Mol Life Sci

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy.

Published: November 2020

The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF-κB generally have opposing effects in cancer cells. While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly studied in relation to its ability to regulate p53. This has revealed the importance of the crosstalk between NF-κB, p53 and other crucial cell signaling pathways. This review analyzes the various mechanisms by which NF-κB regulates the activity of p53 and the role of p53 on NF-κB activity.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104960PMC
http://dx.doi.org/10.1007/s00018-020-03524-9DOI Listing

Publication Analysis

Top Keywords

p53 nf-κb
12
p53
9
p53 activity
8
transcription factor
8
nf-κb
6
nf-κb role
4
role nuclear
4
nuclear factor-kappa
4
factor-kappa regulation
4
regulation p53
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!