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Filename: drivers/Session_files_driver.php
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Function: require_once
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Function: _error_handler
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Function: _error_handler
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: models/Detail_model.php
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Function: strpos
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Function: insertAPISummary
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Filename: helpers/my_audit_helper.php
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Function: str_replace
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Function: formatAIDetailSummary
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Filename: controllers/Detail.php
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File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Objective: To investigate the efficacy and safety of intensive maintenance chemotherapy regimen for treatment of children and adolescents with lymphoblastic lymphoma at stage Ⅲ-Ⅳ.
Methods: The clinical data of 87 children and adolescents with lymphoblastic lymphoma at stage Ⅲ-Ⅳ were analyzed retrospectively from July 2009 to July 2015. All patients received the treatment of modified NHL-BFM-90/95 regimen, and divided into 2 groups: the control group (62 patients) with conventional maintenance chemotherapy regimen, and the intensive regimen group (25 patients) with intensive maintenance chemotherapy regimen. The event-free survival (EFS) rate and overall survival (OS) rate during follow-up for 5 years, recurrence rate, mortality, and toxic and side effects were compared between 2 groups.
Results: There was no significant difference in the EFS rate and OS rate after follow-up for 5 years between 2 groups (P>0.05). There was no significant difference in the EFS rate and OS rate after follow-up for 5 years between clinical stage for Ⅲ and Ⅳ, immunotyping for T-LBL and B-LBL and morderate risk and high risk in 2 groups (P<0.05). There was no significant difference in the recurrence rate and mortality after followed-up between 2 groups (P>0.05). The incidence of myelosuppression for Ⅲ-Ⅳ grade during maintenance therapy in intensive regimen group were significantly higher than that in control group (P<0.05).
Conclusion: Compared with conventional maintenance chemotherapy regimen, intensive maintenance chemotherapy regimen in the treatment of children and adolescents with lymphoblastic lymphoma for stage Ⅲ-Ⅳ possess the same survival benefit, but may cause increased severe bone marrow suppression risk.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.028 | DOI Listing |
Cancer Treat Rev
November 2024
Upper Gastrointestinal and Endocrine Tumor Unit, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Neuroendocrine carcinomas are rare and aggressive malignancies, often diagnosed at advanced stages, leading to poor prognosis. Platinum-based chemotherapy is the standard first-line treatment for advanced neuroendocrine carcinomas; however after achieving response no consensus exists on maintenance therapies and the results are inconsistent. This review examines the role of maintenance therapy following response to first-line chemotherapy in gastroenteropancreatic neuroendocrine carcinomas.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Background: The absolute overall survival (OS) improvement with preoperative chemotherapy or chemoradiotherapy in locally advanced non-small cell lung cancer (NSCLC) patients is controversial and unsatisfactory. We designed this trial to explore the efficacy and safety of perioperative sintilimab plus platinum-based chemotherapy for potentially resectable stage IIIB NSCLC to facilitate further optimization of this therapeutic strategy.
Methods: Patients diagnosed with stage IIIB NSCLC through invasive staging approaches and/or PET/CT scans and evaluated as having a high probability of radical resection of the primary lesion and metastatic lymph nodes with clear pathological margins by a multidisciplinary team were enrolled in this open-label, single-arm, phase II trial at a single centre in China.
J Int Med Res
December 2024
Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with the poorest prognosis among all types of lung cancer. Developing an effective comprehensive strategy remains a key focus. We herein present the first documented case of a 68-year-old man with limited-stage SCLC who has maintained a complete response (CR) for over 30 months to date.
View Article and Find Full Text PDFAm J Case Rep
December 2024
Department of Thoracic Surgery, Linyi People's Hospital, Linyi, Shandong, China.
BACKGROUND ROS1 fusion-positive locally-advanced lung adenocarcinoma is a rare malignant tumor with no clear neoadjuvant therapy guidelines and a poor prognosis. This report describes a 49-year-old man with a ROS1 fusion-positive locally-advanced lung adenocarcinoma with a pathological complete response (pCR) to the tyrosine kinase inhibitor crizotinib combined with chemotherapy. CASE REPORT A 49-year-old Chinese man visited the hospital with a cough and phlegm that began over 20 days ago.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Urology, Qilu Hospital of Shandong University (Qingdao), Qingdao, China.
Background: Increasing evidence indicates that cancer stem cells (CSCs) and cancer stem-like cells form a special subpopulation of cells that are ubiquitous in tumors. These cells exhibit similar characteristics to those of normal stem cells in tissues; moreover, they are capable of self-renewal and differentiation, as well as high tumorigenicity and drug resistance. In prostate cancer (PCa), it is difficult to kill these cells using androgen signaling inhibitors and chemotherapy drugs.
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