[Clinical Treatment and Prognosis of 61 Patients with Extranodal NK/T Cell Lymphoma].

Objective: To investigate the pathological features, clinical characteristics, treatment outcomes and prognosis influcing factors in patients with extranodal NK/T cell lymphoma(ENKTL).

Methods: Clinical data of 61 patients with ENKTL treated in oncology and hematology department of Southwest Medical University Affiliated Hospital from April 2013 to August 2018 were restrospectively analyzied, the pathological features, clinical characteristics, therapeutic strategy and prognosis-related factors were explored.

Results: The median follow-up was 20 months（range 3 to 81 months）and median age was 48 years old（range 15 to 70 years old）, the proportion of male and female patients was 1.5∶1. The overall survival(OS) rate of 1,3 years was 67.2%,26.2% respectively and progression-free survival(PFS) rate was 63.9%,24.5% respectively. Univariate analysis showed that the percentage of Ki-67 affected efficacy of initial treatment; Ann Arbor stage, LDH level, EBER test, anemia, IPI score, B-symptoms, bone marrow involvement, lymphnodes involvement, monotherapy, initial treatment effect were factors associated with prognosis. According to multivariate analysis, the initial coure remission was the independent factors for prognosis. More survival benefit could be obtained by receiving radiotherapy especially for early stage patients.

Conclusion: Initial course remission is independent factors influencing prognosis. For patients in early stage(IE to IIE), radiotherapy or combined radiotherapy with chemotherapy is superior to chemotherapy alone; The patients diagnosed with IIIE or IVE show rapid progression of disease and poor outcome, whether they are treated with combined treatment or monotherapy. New methods such as hematopoietic stem cell infusion and CAR-T can be considered.