Background: Full-field deep ablative laser resurfacing is a popular method for skin rejuvenation due to maximum improvement in a single treatment. However, it is associated with disadvantages such as pain, prolonged erythema, swelling, crusting, infections, pigmentary changes, and scarring. Patients are increasingly seeking less invasive options with comparable effect.
Aims: The aim of this retrospective study was to evaluate the safety and efficacy of full-face resurfacing using a combination of full spot and fractional erbium (Er:YAG) laser resurfacing.
Patients/methods: About 109 patients, mostly females over 50 years old, were treated with a two-phase protocol: full spot ablation (5 J/cm , three passes) and fractional ablation (132 J/cm , 5% coverage, three passes). We recorded time to re-epithelization and duration of post-treatment erythema. Any side effects observed at follow-up or reported by the patient were recorded. Patient satisfaction questionnaire and blinded evaluation of pre- and post-treatment photographs were used to assess efficacy.
Results: A single session was performed in 96% of cases. Postoperative re-epithelization lasted on average 6.4 ± 2.9 days. Post-treatment erythema lasted on average 13.8 ± 15.2 days. One patient had hyperpigmentation, one infection, one hypo-pigmentation, and one ulcer. All side effects resolved without complications. According to the blinded assessment of photographs, 78% of patients showed improvement. About 97% of patients were satisfied with the results of the treatment.
Conclusions: A combination of fractional and full spot ablative Er:YAG laser is a safe and effective option for full-face resurfacing.
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http://dx.doi.org/10.1111/jocd.13450 | DOI Listing |
Eur Heart J
January 2025
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 2199 Lishui Rd, Nanshan, Shenzhen, Guangdong Province 518055, China.
Background And Aims: Lackluster results from recently completed gene therapy clinical trials of VEGF-A delivered by viral vectors have heightened the need to develop alternative delivery strategies. This study aims to demonstrate the pre-clinical efficacy and safety of extracellular vesicles (EVs) loaded with VEGF-A mRNA for the treatment of ischaemic vascular disease.
Methods: After encapsulation of full-length VEGF-A mRNA into fibroblast-derived EVs via cellular nanoporation (CNP), collected VEGF-A EVs were delivered into mouse models of ischaemic injury.
J Am Mosq Control Assoc
January 2025
Anastasia Mosquito Control District, 120 EOC Drive, St. Augustine, FL, 32092.
Aerial applications of pesticides for adult mosquito control have emerged as effective tools in integrated mosquito management due to wider reach compared with ground-based methods. A key determinant for efficacy is the swath or line of spray deposition. This study aimed to assess the potential of aerial buffer sprays, which specifically target mosquito habitats, in comparison to traditional full-area aerial and ground-based applications.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Mechanical Engineering Department, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States.
Mechanical properties of engineered connective tissues are critical for their success, yet modern sensors that measure physical qualities of tissues for quality control are invasive and destructive. The goal of this work was to develop a noncontact, nondestructive method to measure mechanical attributes of engineered skin substitutes during production without disturbing the sterile culture packaging. We optimized a digital holographic vibrometry (DHV) system to measure the mechanical behavior of Apligraf living cellular skin substitute through the clear packaging in multiple conditions: resting on solid agar as when the tissue is shipped, on liquid media in which it is grown, and freely suspended in air as occurs when the media is removed for feeding.
View Article and Find Full Text PDFData Brief
February 2025
Agroscope, Socio-Economics Group, Tänikon 1, 8356 Ettenhausen, Switzerland.
This article describes data from an online survey conducted with the Swiss public from the two biggest language regions (German and French) in Switzerland. The survey was conducted in February 2023. Participants were recruited through a professional panel provider and quotas were used for age, gender and language region.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Pediatrics, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand.
Objective: Infants are at a high risk of developing anaemia, which can arise from various causes, including inappropriate feeding practices. However, few infants attend anaemia screening programmes due to poor cooperation and being time-consuming. This study evaluated the accuracy of noninvasive total haemoglobin (Hb) spot-check monitoring as part of anaemia screening in healthy infants, compared with the conventional laboratory method.
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