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Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD/SIRT1 Pathway.
Biomolecules
November 2024
Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Actinic keratosis (AK) is a precursor to invasive squamous cell carcinoma, making early diagnosis and treatment essential to prevent progression. Among available therapeutic options, nicotinamide (NAM) has shown potential in reducing AK progression. NAM is a precursor of nicotinamide adenine dinucleotide (NAD), which activates sirtuin (SIRT)1, a protein with anti-cancer properties.
View Article and Find Full Text PDFImpact of light dose and fluence rate on the efficacy and tolerability of topical 5-ALA photodynamic therapy for actinic keratoses: A randomized, controlled, observer-blinded intrapatient comparison study.
J Eur Acad Dermatol Venereol
December 2024
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Background: Conventional photodynamic therapy (cPDT) is an effective treatment option for field cancerization and multiple actinic keratoses (AK). The main side effect of cPDT is pain during illumination which in severe cases might necessitate early termination of treatment. Modification of treatment parameters such as light dose and fluence rate is a promising approach to mitigate PDT-associated pain.
View Article and Find Full Text PDFClinical Study of Intradermal Injection of Non-Crosslinked Sodium Hyaluronate Combined With Human Epidermal Growth Factor in the Treatment of Skin Barrier Injury in Plateau Area.
J Cosmet Dermatol
December 2024
Department of Plastic Surgery, Affiliated Calmette Hospital of Kunming Medical University, Kunming, China.
Background: The Yunnan-Guizhou Plateau's high-altitude setting is characterized by intense solar ultraviolet radiation, a significant environmental stressor that frequently leads to skin barrier damage. This damage presents clinically as erythema, itching, and desquamation, underscoring the need for effective reparative interventions.
Aims: The objective of this study was to assess the therapeutic efficacy of a novel treatment protocol that integrates non-crosslinked hyaluronic acid (HA) injection with microneedle application of human epidermal growth factor (hEGF) for the restoration of skin barrier function in regions of high altitude.
Evaluating Difluoromethylornithine Safety and Efficacy for Non-Melanoma Skin Cancer Chemoprevention: A Systematic Review.
J Cutan Med Surg
November 2024
Cancer Research Program, McGill University Health Centre Research Institute, Montreal, QC, Canada.
Article Synopsis
- Recent FDA approval of difluoromethylornithine (DFMO) has sparked interest in its potential for preventing various cancers, including keratinocyte carcinomas (KCs), beyond its initial purpose for neuroblastoma in children.
- A systematic review of 12 studies involving 1,618 predominantly Caucasian patients revealed mixed results, with oral DFMO showing a significant reduction in KCs in only 24% of cases, while topical DFMO showed modest effectiveness in reducing actinic keratosis.
- Overall, the current evidence does not strongly support the use of oral DFMO, whereas topical DFMO may offer a better option for certain patients in preventing skin cancer.
Dermoscopy Training Course Improves Ophthalmologists' Accuracy in Diagnosing Atypical Pigmented Periorbital Skin Lesions.
Diagnostics (Basel)
November 2024
Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Article Synopsis
- Facial pigmented skin lesions are common, especially in South-European countries, and can be either malignant or benign; diagnosing them can be challenging, even for specialists like dermatologists.* -
- A study was conducted to assess the impact of a one-day dermoscopy training course on ophthalmologists, focusing on their ability to evaluate periorbital pigmented lesions through clinical and dermoscopic analysis.* -
- Results showed that before the training, ophthalmologists had an accuracy of 63.7%, but after the course, their sensitivity improved, indicating a positive effect of the training on their diagnostic skills.*
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