AI Article Synopsis
- - This study analyzed various leaf extracts (hexane, chloroform, ethyl acetate, ethanol, aqueous) and a total oligomer flavonoids (TOFs) extract for their phytochemical content, specifically looking at phenols and flavonoids, which were highest in the TOF extract.
- - Antibacterial properties were evaluated using the disc diffusion and microdilution methods against standard and resistant clinical bacterial strains, finding that the TOF extract exhibited the strongest antibacterial activity.
- - The study also explored the synergistic effects of combining the TOF extract with antibiotics (amoxicillin and cefotaxime), discovering that the TOF extract greatly enhanced the efficacy of amoxicillin against penicillin-resistant bacteria
Article Abstract
This study aimed to determine phytochemical contents, antibacterial properties, and antibiotic modulating potential of leaf extracts: hexane, chloroform, ethyl acetate, ethanol, and aqueous extracts as well as an extract enriched with total oligomer flavonoids (TOFs). The TOF extract contained the highest value of phenols and flavonoids. Rutin, luteolin, gallic acid, and ellagic acid were determined by HPLC analysis of this extract. The antibacterial activity was assayed by the disc diffusion method and microdilution method against and standard ATCC strains and clinical isolates resistant strains. The TOF extract was the most active against all tested strains. The checkerboard method was used for the determination of synergy between two antibiotics (amoxicillin and cefotaxime) and leaf extracts. The best synergistic interaction was found with TOF extract combined with amoxicillin for penicillin-resistant and penicillin-resistant . These results can be assigned to tannins, flavonoids, and phenolic acids found in leaf extracts. Pomegranate leaf extracts or active compounds isolated from these extracts could be used to fight the emergence and spread of resistant bacterial strains.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150692 | PMC |
| http://dx.doi.org/10.1155/2020/8271203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Potent antiviral action detected in extracts against .
Drug Dev Ind Pharm
January 2025
Laboratory of Virology and Cellular Technology, Department of Chemistry, Biotechnology, and Bioprocess Engineering, Universidade Federal de São João del-Rei, Ouro Branco, MG, Brazil.
Background: , a notable plant species, has garnered interest for its medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A vaccine for Chikungunia virus is still under evaluation and no specific antiviral drug has been licensed to date.
Objective: The work investigated antiviral activity of ethyl acetate (EAEF) and methanolic (EMF) extracts from leaves in mammalian cells exposed to (CHIKV).
Estimation of Secondary Metabolites, Nutrients, Minerals, and Anti-Inflammatory and Antidiarrheal Agents in Heliotropium rariflorum Stocks at Two Phenological Stages.
Chem Biodivers
January 2025
Department of Agricultural Chemistry & Biochemistry, The University of Agriculture, Peshawar, Pakistan.
The medicinal value of plants depends on minerals and nutrients and their complexation with chemotherapeutic compounds. The present study aimed to evaluate the phytochemical composition with anti-inflammatory and antidiarrheal potential of Heliotropium rariflorum. Among nutrients, fibers were maximum (25.
View Article and Find Full Text PDFInvestigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis.
PLoS One
January 2025
Research Centre for Plant Conservation, Botanic Gardens and Forestry, National Research and Innovation Agency, Bogor, Indonesia.
One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research to predict the active compounds as α-glucosidase inhibitors from this extract. Both multivariate statistical analysis and machine learning approaches were used to improve the confidence of the predictions.
View Article and Find Full Text PDFIdentification, Biocontrol and Plant Growth Promotion Potential of Endophytic Streptomyces sp. a13.
Curr Microbiol
January 2025
Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati, Assam, 781035, India.
Medicinal plants often harbour various endophytic actinomycetia, which are well known for their potent antimicrobial properties and plant growth-promoting traits. In this study, we isolated an endophytic actinomycetia, A13, from the leaves of tea clone P312 from the MEG Tea Estate, Meghalaya, India. The isolate A13 was identified as Streptomyces sp.
View Article and Find Full Text PDFInvestigating the Synergistic Interactions Between AgNPs and NiCl on the Morpho-Physiological Trajectories of Zea mays L. Through Comprehensive Characterization at Seedling Stage.
Microsc Res Tech
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Green synthesis of nanoparticles (NPs) is preferred for its affordability and environmentally friendly approach. This study explored the synthesis and characterization of silver NPs (AgNPs) and examined their impact on the growth of Zea mays, both alone and in combination with nickel chloride (NiCl). A methanolic leaf extract was combined with silver nitrate to synthesize AgNPs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!