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The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress.
Neuroimmunomodulation
December 2024
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Introduction: Common mental disorders, such as anxiety disorders, depression, and posttraumatic stress disorder (PTSD), present a substantial health and economic burden. The gut microbiome has been associated with these psychiatric disorders via the microbiome-gut-brain axis. However, previous studies have focused on the associations between the gut microbiome and common mental disorders in European, North American, and Asian populations.
View Article and Find Full Text PDFComparison of the aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis between children and adults in southern China: a retrospective, cohort study.
BMJ Open
November 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Article Synopsis
- - The study compares the causes, bacterial isolates, and antibiotic susceptibility of endophthalmitis in children versus adults, revealing trauma as the primary cause in both groups, with children experiencing it more frequently.
- - In terms of microbial isolates, specific bacteria were prevalent in each age group: pediatric cases mostly involved certain species, while coagulase-negative staphylococci were more common in adults; fungi also played a notable role in adults' postoperative infections.
- - Children showed higher antibiotic susceptibility rates compared to adults for the majority of tested antibiotics, with levofloxacin being the most effective for children and ofloxacin for adults.
From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach.
Life (Basel)
October 2024
Skin Bank Unit, Azienda Ospedaliera Universitaria Senese (AOUS), 53100 Siena, Italy.
Given progressive population ageing and the increase in the number of patients with comorbidities, the management of chronic and/or hard-to-heal wounds (HHWs) nowadays represents a common problem in many clinical settings. In these cases, standard strategies may not be sufficient. Autologous grafting represent the gold standard for permanent wound closure, but is almost never realized when the skin loss is extensive/the patient is young.
View Article and Find Full Text PDFCan bone SPECT/CT determine optimal sites for microbiological identification in post-traumatic or chronic osteomyelitis of extremities?
Injury
December 2024
Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, South Korea. Electronic address:
Introduction: Accurate microbiological identification is crucial when managing chronic osteomyelitis (COM) and post-traumatic osteomyelitis (PTO). Although bone single photon emission computed tomography/computed tomography (SPECT/CT) has helped in localizing osteomyelitis lesions, its effectiveness in guiding microbiological sampling remains unclear. This study aimed to determine whether bone SPECT/CT can improve microbiological identification rates in COM or PTO of the extremities.
View Article and Find Full Text PDFComplex trauma sequelae: Mycobacterium goodii and Priestia endophytica Hardware infection in a patient with Ehlers-Danlos syndrome.
BMC Infect Dis
September 2024
Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Article Synopsis
- A 26-year-old man with Ehlers-Danlos syndrome and chronic ear infections faced a complex medical situation after a car accident that led to a leg amputation and leg fracture requiring surgical fixation.
- He presented with severe pain and discharge from the injured area, but initial antibiotic treatments did not improve his condition, leading to further medical evaluations.
- Ultimately, he was diagnosed with a rare infection caused by Mycobacterium goodii, which improved with targeted antibiotic therapy, highlighting the difficulties in diagnosing infections in patients with compromised immune systems.
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