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Not All Antiseptic Solutions Are Equivalent in Removing Biofilm: A Comparison Across Different Orthopaedic Surfaces.
J Bone Joint Surg Am
January 2025
Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, New York, NY.
Background: Antiseptic solutions are commonly utilized during total joint arthroplasty (TJA) to prevent and treat periprosthetic joint infection (PJI). The purpose of this study was to investigate which antiseptic solution is most effective against methicillin-sensitive Staphylococcus aureus (MSSA) and Escherichia coli biofilms established in vitro on orthopaedic surfaces commonly utilized in total knee arthroplasty: cobalt-chromium (CC), oxidized zirconium (OxZr), and polymethylmethacrylate (PMMA).
Methods: MSSA and E.
Nosocomial , , , and : Sensitivity to Chlorhexidine-Based Biocides and Prevalence of Efflux Pump Genes.
Int J Mol Sci
January 2025
Department of Microbiology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
The widespread use of disinfectants and antiseptics has led to the emergence of nosocomial pathogens that are less sensitive to these agents, which in combination with multidrug resistance (MDR) can pose a significant epidemiologic risk. We investigated the susceptibility of nosocomial , , , and to a 0.05% chlorhexidine (CHX) solution and a biocidal S7 composite solution based on CHX (0.
View Article and Find Full Text PDFEmerging biofilm formation and disinfectant susceptibility of ESBL-producing Klebsiella pneumoniae.
Sci Rep
January 2025
Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Klebsiella pneumoniae is an opportunistic pathogen responsible for various infections in humans and animals. It is known for its resistance to multiple antibiotics, particularly through the production of Extended-Spectrum Beta-Lactamases (ESBLs), and its ability to form biofilms that further complicate treatment. This study aimed to isolate and identify K.
View Article and Find Full Text PDFUnraveling Antimicrobial Resistance Dynamics in Mycoplasma gallisepticum: Insights Into Antibiotic and Disinfectant Interactions.
Vet Med Sci
January 2025
Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
A major risk to the poultry industry is antimicrobial resistance (AMR), specifically with regard to Mycoplasma gallisepticum (MG) infections. The sensitivity patterns of 100 MG isolates to biocides and antibiotics were examined in this study to clarify the interactions between antimicrobial agents and resistance mechanisms. The antimicrobial activity against MG was assessed using broth microdilution, and the results are shown as the minimum inhibitory concentration (MIC) for each strain, the MIC distribution (range), the MIC, and/or the MIC.
View Article and Find Full Text PDFUnveiling the role of rubber seals in the generation of decentralized disinfection by-products in chlorinated water distribution systems.
Chemosphere
January 2025
University of Chinese Academy of Sciences, Beijing, 100049, China; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. Electronic address:
The degradation of rubber seal (RS), particularly ethylene-propylene-diene (EPDM), in the drinking water networks has been confirmed, yet the role of RS as a disinfection by-product (DBP) precursor remains unknown. This study provides explicit proof of the formation of halogenated disinfection by-products (X-DBPs) from RS in chlorinated drinking water within water supply systems. Over time, exposure to chlorinated water ages RS, releasing high levels of organic compounds, which act as DBP precursors.
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