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Estrogen Receptors and Endometriosis. | LitMetric

Estrogen Receptors and Endometriosis.

Int J Mol Sci

INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, CEDEX 04, 31 432 Toulouse, France.

Published: April 2020

AI Article Synopsis

  • Endometriosis is a common and chronic inflammatory condition that negatively affects reproduction, health, and quality of life, largely driven by high levels of estrogen.
  • Hormonal treatments aim to reduce estrogen production since endometriotic cells show altered estrogen receptor levels compared to healthy tissue, notably higher ERβ and lower ERα levels.
  • The review explores the relationship between endometriosis and estrogen receptors, highlighting recent treatment advances and the need for a deeper understanding of estrogen receptor mechanisms to develop new therapies.

Article Abstract

Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consistently observed endocrine feature of endometriosis. mRNA and protein levels of estrogen receptors (ER) are different between a normal healthy endometrium and ectopic/eutopic endometrial lesions: endometriotic stromal cells express extraordinarily higher ERβ and significantly lower ERα levels compared with endometrial stromal cells. Aberrant epigenetic regulation such as DNA methylation in endometriotic cells is associated with the pathogenesis and development of endometriosis. Although there is a large body of data regarding ERs in endometriosis, our understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis remains incomplete. The goal of this review is to provide an overview of the links between endometriosis, ERs and the recent advances of treatment strategies based on ERs modulation. We will also attempt to summarize the current understanding of the molecular and cellular mechanisms of action of ERs and how this could pave the way to new therapeutic strategies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215544PMC
http://dx.doi.org/10.3390/ijms21082815DOI Listing

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