Two iPSC clones, NCCSi008-A and NCCSi008-B, were generated from a healthy male individual of Indian origin by reprogramming his CD4 T cells with an integration free Sendai viral vector. The established iPSC clones showed high alkaline phosphatase (ALP) activity, expression of pluripotency markers, a normal male karyotype consistent with the donor gender (46, XY) and has potential for multi-lineage differentiation. These iPSC lines of Indian origin would serve as valuable resources for disease modeling, drug development and screening.
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| http://dx.doi.org/10.1016/j.scr.2020.101765 | DOI Listing |
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Article Synopsis
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- By analyzing multiple hiPSC clones from a single donor, researchers categorized them into productive (PC) and non-productive (NPC) groups based on their differentiation efficiency, uncovering distinct biological profiles.
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