AI Article Synopsis
- Aerobic respiration is crucial for survival in eukaryotes, and how organisms sense oxygen plays a key role in their ability to thrive.
- Plants and animals have developed different mechanisms for oxygen sensing, including the destruction of transcription factors and direct oxygen detection by specific enzymes.
- Understanding these sensing systems can yield insights for developing therapeutic strategies for humans and creating crops that can better withstand stress.
Article Abstract
Aerobic respiration is essential to almost all eukaryotes and sensing oxygen is a key determinant of survival. Analogous but mechanistically different oxygen-sensing pathways were adopted in plants and metazoan animals, and include ubiquitin-mediated degradation of transcription factors and direct sensing via non-heme iron(Fe)-dependent-dioxygenases. Key roles for oxygen sensing have been identified in both groups, with downstream signalling focussed on regulating gene transcription and chromatin modification to control development and stress responses. Components of sensing systems are promising targets for human therapeutic intervention and developing stress-resilient crops. Here, we review current knowledge about the origins, commonalities and differences between oxygen sensing in plants and animals.
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| http://dx.doi.org/10.1016/j.cub.2020.03.021 | DOI Listing |
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