Background: We present the largest UK single institute robotic radical hysterectomy (RRH) case series for the management of cervical cancer (CC).
Methods: Data were collected on women who had a RRH as primary treatment for stage 1b1 CC between December 2009 and December 2018.
Results: Ninty women had a robotic hysterectomy. Five-year follow-up data were available for 30%. The disease-free survival at 5 years was 89.6%. Overall survival at 3 and 5 years for death from any cause was 96.1% and 91.4%, respectively. The overall 5-year survival for death from disease only was 92.8%. Overall survival by tumour size alone showed that women with tumours less than 2 cm had a 98.3% 5-year survival compared to 83.4% for tumour size greater than 2 cm. Irrespective of tumour size, those that had no evidence of lymphovascular space invasion had a 100% 5-year survival.
Conclusion: Our preliminary data supports the oncological safety of RRH in a selective cohort of patients with stage 1b1 CC.
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http://dx.doi.org/10.1002/rcs.2116 | DOI Listing |
Viruses
October 2024
ICMR-National Institute of Research in Tribal Health, Jabalpur 482003, Madhya Pradesh, India.
Since the first reported case of COVID-19 in December 2019, several SARS-CoV-2 variants have evolved, and some of them have shown higher transmissibility, becoming the prevalent strains. Genomic epidemiological investigations into strains from different time points, including the early stages of the pandemic, are very crucial for understanding the evolution and transmission patterns. Using whole-genome sequences, our study describes the early landscape of SARS-CoV-2 variants in central India retrospectively (including the first known occurrence of SARS-CoV-2 in Madhya Pradesh).
View Article and Find Full Text PDFCell Rep
October 2024
Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada. Electronic address:
During periods of nutrient scarcity, many animals undergo germline quiescence to preserve reproductive capacity, and neurons are often necessary for this adaptation. We show here that starvation causes the release of neuronal microRNA (miRNA)/Argonaute-loaded exosomes following AMP kinase-regulated trafficking changes within serotonergic neurons. This neuron-to-germline communication is independent of classical neurotransmission but instead relies on endosome-derived vesicles that carry a pro-quiescent small RNA cargo to modify germline gene expression.
View Article and Find Full Text PDFBMC Womens Health
July 2024
Department of Gynecology, Gunma Prefectural Cancer Center, 617-1 Takabayashi-nishi, Ota, Japan.
J Clin Med
July 2024
Department of Obstetrics and Gynecology, Educational Foundation of Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki 569-8686, Osaka, Japan.
bioRxiv
June 2024
School of Physics and Astronomy, College of Science, Rochester Institute of Technology, Rochester, NY 14623, USA.
The nucleolus is a multicomponent structure made of RNA and proteins that serves as the site of ribosome biogenesis within the nucleus. It has been extensively studied as a prototype of a biomolecular condensate whose assembly is driven by phase separation. While the steady-state size of the nucleolus is quantitatively accounted for by the thermodynamics of phase separation, we show that experimental measurements of the assembly dynamics are inconsistent with a simple model of a phase-separating system relaxing to its equilibrium state.
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