With the emergence of support for diet in the maintenance of cognition, clinicians have been justifiably eager to promote diet recommendations for their older patients. But popular diets, such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH), and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), have not been shown to benefit cognition among patients who already have dementia or cognitive decline. In our experience, promoting these restrictive diets can be detrimental to patients with dementia who are already prone to eating disturbance; vulnerable to malnutrition; and, if underweight, demonstrate increased mortality. Moreover, we have seen both patient and caregiver satisfaction negatively affected by dietary modification. Clinicians need to be aware that any dietary recommendations for patients with dementia should be mitigated by the lack of evidence for improvement in cognition, the risks for exacerbating poor nutrition, and the potential for further limiting their quality of life.
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http://dx.doi.org/10.1002/trc2.12011 | DOI Listing |
J Gen Intern Med
January 2025
Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.
Background: Previous reports suggest patient and caregiver lack of awareness of dementia. Little is known about how this varies by ethnicity and how informal (family) caregiver burden is associated with knowing a dementia diagnosis.
Objective: To investigate whether participants with probable dementia were aware of a diagnosis provided by a physician and how this differed among Mexican American and non-Hispanic White participants; whether having a primary care physician was associated with dementia diagnosis unawareness; and the association of dementia diagnosis unawareness with caregiver burden.
Neurol Sci
January 2025
Department of Neurology, Provincial Hospital of Bolzano (SABES- ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, 39100, Italy.
Introduction: Vortioxetine is a multimodal antidepressant with a high tolerability profile. Recent evidence suggests a role for vortioxetine in improving cognitive function and reducing functional disability linked to depression. We conducted a systematic review on the use of vortioxetine in different neurological disorders.
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View Article and Find Full Text PDFUrogynecology (Phila)
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UConn Health, Farmington, CT.
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View Article and Find Full Text PDFAlzheimers Dement
January 2025
Rush University Medical Center, Chicago, Illinois, USA.
Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course.
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