There is limited understanding of adverse health effect associations with chemical constituents of fine particulate matter (PM) as well as the underlying mechanisms. We outlined a workflow to assess metrics, beyond concentration, using household and personal PM filter samples collected in India as a proof of concept for future large-scale studies. Oxidative potential, chemical composition (polycyclic aromatic hydrocarbons and elements), and bioactivity (developmental exposures in zebrafish) were determined. Significant differences were observed in all metrics between personal and household PM samples. This work established methods to characterize multiple metrics of PM to ultimately support the identification of more health-relevant metrics than concentration.
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http://dx.doi.org/10.1016/j.atmosenv.2020.117379 | DOI Listing |
Int J Antimicrob Agents
December 2024
Department of Pharmacy, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510163, China. Electronic address:
Despite the widespread use of voriconazole in antifungal treatment, its high pharmacokinetic and pharmacodynamic variability may lead to suboptimal efficacy, especially in intensive care unit (ICU) patients. Machine learning (ML), an artificial intelligence modeling approach, is increasingly being applied to personalized medicine. The effectiveness of ML models for predicting voriconazole blood concentrations in ICU patients, compared to traditional population pharmacokinetics (popPK) models, has been uncertain until now.
View Article and Find Full Text PDFEpidemics
December 2024
California Department of Public Health Center for Infectious Diseases, 850 Marina Bay Parkway, Richmond, CA 94804, United States. Electronic address:
The effective reproduction number serves as a metric of population-wide, time-varying disease spread. During the early years of the COVID-19 pandemic, this metric was primarily derived from case data, which has varied in quality and representativeness due to changes in testing volume, test-seeking behavior, and resource constraints. Deriving nowcasting estimates from alternative data sources such as wastewater provides complementary information that could inform future public health responses.
View Article and Find Full Text PDFJ Vet Diagn Invest
December 2024
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Evaluating stress in shelter and institutionally owned cats is important to help guide improvements in their welfare. Welfare assessments often focus on behavior metrics and physiologic measurements, such as systemic cortisol levels. The gold standard for measuring acute stress is serum cortisol; measuring cortisol in feces and urine gives reliable time-integrated assessments of acute stress.
View Article and Find Full Text PDFJ Endod
December 2024
Geriatric Dentistry Department, Faculty of Dentistry of Fluminense Federal University, Niteroi, (UFF), Niteroi, RJBrazil; Endodontics Department, Faculty of Dentistry of Fluminense Federal University (UFF), Niteroi, RJ, Brazil; Laboratory of Experimental Culture Cell (LECCel), Faculty of Dentistry of Fluminense, Federal University (UFF), Niteroi, RJ, Brazil. Electronic address:
Introduction: This study assessed a new antimicrobial paste formulation containing nitrofurantoin for regenerative endodontics against multispecies biofilms.
Methods: Four groups of 11 single-root teeth each were tested: Negative control group (BHI + microorganisms); Hoshino 1 conventional tri-antibiotic paste group (1:1:1 ratio); Hoshino 5 group (5:5:5 ratio); Experimental group with nitrofurantoin, ciprofloxacin, and metronidazole. Minimum inhibitory concentrations of each antimicrobial were determined.
Immunity
December 2024
Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:
Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the frequencies of stem-like progenitor-exhausted T (Tex_prog) cells better reflect immunotherapeutic responsivity. Here, we examined the intratumoral cellular interactions that govern the transition to terminal T cell exhaustion. We defined a metric reflecting the intratumoral progenitor exhaustion-to-terminal exhaustion ratio (PETER), which decreased with tumor progression in solid cancers.
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