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Circulating ANGPTL3/8 Concentrations Are Associated With an Atherogenic Lipoprotein Profile and Increased CHD Risk in Swedish Population-Based Studies.
Arterioscler Thromb Vasc Biol
January 2025
Cardiovascular Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. (A.S., R.M.F., F.M.v.H.).
Background: Binding of ANGPTL (angiopoietin-like protein)-3 to ANGPTL8 generates a protein complex (ANGPTL3/8) that strongly inhibits LPL (lipoprotein lipase) activity, as compared with ANGPTL3 alone, suggesting that ANGPTL3/8 concentrations are critical for the regulation of circulation lipoprotein concentrations and subsequent increased coronary heart disease (CHD) risk. To test this hypothesis in humans, we evaluated the associations of circulating free ANGPTL3 and ANGPTL3/8 complex concentrations with lipoprotein concentrations and CHD risk in 2 prospective cohort studies.
Methods: Fasting blood samples were obtained in conjunction with the baseline evaluation of 9479 subjects from 2 population-based Swedish cohorts of middle-aged men and women.
Global burden of cardiovascular diseases attributable to diet low in vegetables from 1990 to 2021 and forecasting the future trends: a population-based study.
Front Cardiovasc Med
January 2025
Xiangya School of Medicine, Central South University, Changsha, China.
Background: This investigation examines the worldwide impact of cardiovascular diseases (CVD) resulting from inadequate vegetable consumption, based on the 2021 Global Burden of Disease Study data.
Method: The study assessed the global, regional, and national repercussions of low vegetable intake on CVD, with a focus on variations among different age and gender demographics. It further analyzed the correlation between disease burden and the Socio-Demographic Index (SDI), and employed an ARIMA model to predict future trends in CVD associated with insufficient vegetable consumption up to 2050.
Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional study.
Lancet Reg Health West Pac
February 2025
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.
Background: To date, comprehensive data on the distribution of chronic kidney disease (CKD), the most prevalent comorbidity in diabetes, among Chinese adults with diabetes is lacking. Additionally, research gaps exist in understanding the association between CKD and cardiovascular health (CVH), an integrated indicator of lifestyle and metabolic control, within a nationwide sample of Chinese adults with diabetes.
Methods: A nationally community-based cross-sectional survey was conducted in 2018-2020.
Corrigendum to "Current and future burden of ross river virus infection attributable to increasing temperature in Australia: a population-based study" the Lancet Regional Health-Western Pacific 2024;48: 101124.
Lancet Reg Health West Pac
October 2024
School of Public Health, The University of Adelaide, Adelaide, South Australia 5005, Australia.
[This corrects the article DOI: 10.1016/j.lanwpc.
View Article and Find Full Text PDFReal-world treatment patterns and survival outcomes in men with metastatic castration-resistant prostate cancer in Finland: a national, population-based cohort study.
Acta Oncol
January 2025
Medaffcon Oy, Espoo, Finland.
Background: Metastatic castration-resistant prostate cancer (mCRPC) treatment is advancing yet Nordic, real-world evidence for its use is scarce. In this population-based cohort study, we describe characteristics of patients with mCRPC, and their treatment patterns and survival outcomes in Finland.
Methods: Incident patients with mCRPC diagnosed during 2013-2021 were identified from data lakes in two large and representative, Finnish hospital districts, and linked to data on drug purchases and causes of death from national registries.
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