Broadening the application of recombineering technologies in biotechnologically important bacteria poses significant challenges. Aparicio et al. present a vital breakthrough for efficient single-stranded recombineering by utilizing a thermoinducible system in Pseudomonas putida. This offers a simple genome-editing tool towards creating superior biocatalysts for the synthesis of chemicals and for bioremediation endeavors.
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http://dx.doi.org/10.1016/j.tibtech.2020.03.014 | DOI Listing |
PLoS One
January 2025
Maple Health Group, LLC, New York, United States of America.
The US faces substantial demographic and geographic disparities in both HIV burden and access to pre-exposure prophylaxis (PrEP), an effective strategy to prevent HIV acquisition. Long-acting cabotegravir (CAB) is a novel, injectable PrEP option which demonstrated superior reduction in risk of HIV acquisition compared to daily-oral PrEP in the HPTN083 trial. We modelled the impact of increased PrEP initiations and the introduction of long-acting CAB on HIV incidence among men who have sex with men (MSM) in Atlanta, Georgia, a population with a high burden of HIV.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: The common marmoset (Callithrix jacchus) is an important animal model in neuroscience and neurological diseases, presenting primate-specific evolutionary features such as an expanded frontal cortex. We established a new consortium with funding support from the National Institute on Aging to generate, characterize, and validate MArmosets as Research MOdels of AD (MARMO-AD). This consortium develops and studies gene-edited marmoset models carrying genetic risk for AD, comparing them against wild-type aging marmosets from birth throughout their lifespan, using non-invasive longitudinal assessments.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Social and health-related disparity factors are important predictors of brain health in low and middle-income countries (LMIC). Social predictors of cognition have a higher impact on brain health among LMICs than classic demographic factors, such as age and sex. This study aimed to evaluate the impact of modifiable and non-modifiable social and health-related factors on cognition in a Brazilian population-based cohort.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UC Davis Alzheimer's Disease Center, Walnut Creek, CA, USA.
Background: The Good Life program for healthy brain aging (TGL) is an online program for positive lifestyle change that is made up of exercise, diet and social support classes. Since 2020, The Good Life has served thousands of older Californians. Currently, we host 17 classes weekly for our 750 active members (in both English and Spanish).
View Article and Find Full Text PDFBackground: High formal education level is widely recognized as a protective factor against cognitive decline, influenced by the reserve hypothesis. However, in multiple studies educational experience is confounded with cultural and socioeconomic factors, leading to contradictory findings. Factors such as an individual's living environment, including socioeconomic conditions, rather than individual variables such as education, are hypothesized to be factors influencing cognitive decline.
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