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Vaccine Efficacy and Safety in Patients with Celiac Disease.
Vaccines (Basel)
November 2024
Gastroenterology Unit, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Policlinico G.B. Rossi & University of Verona, 37134 Verona, Italy.
Celiac disease (CD) is an autoimmune disorder caused by gluten intake in genetically predisposed individuals. This article provides an overview of the available data on the risks of infectious diseases and the mechanisms involved in CD, including a detailed analysis of vaccine efficacy, immunogenicity, and safety. The published articles were retrieved from the PubMed database using the terms "celiac disease", "efficacy", "hyposplenism", "immune response", "infections", "immunization", "immunogenicity", "safety", "vaccination", and "vaccine".
View Article and Find Full Text PDFPhenotype and Treatment Options for Mesenteric Lymph Node Cavitating Syndrome in Coeliac Disease: A Case Series and Literature Review.
J Clin Med
September 2024
Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK.
Article Synopsis
- There is limited data on mesenteric lymph node cavitation syndrome (MLNCS), a rare and serious condition linked to coeliac disease, which can lead to central necrosis in enlarged lymph nodes; the largest related study dates back to 1984 and noted a poor prognosis.
- A recent study from 2000 to 2023 included 51 patients, revealing that common symptoms were weight loss (80%) and diarrhea (65%), with a significant number having persistent villous atrophy (88%) and hyposplenism (80%).
- The prognosis for MLNCS is poor, with a 43% overall mortality rate mainly due to complications like cachexia and infections; current treatment methods appear inadequate, suggesting a
Celiac Disease-Related Conditions: Who to Test?
Gastroenterology
June 2024
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York.
Article Synopsis
- - Celiac disease (CeD) is a chronic condition triggered by gluten in those genetically prone, affecting about 1% of the population, yet it remains often overlooked despite increasing awareness.
- - Proactively testing high-risk individuals with serology is the best method for identifying undiagnosed CeD, particularly among those with autoimmune diseases or conditions that might mimic CeD symptoms.
- - Recommended screening for CeD includes patients with various specific conditions, and if they undergo upper endoscopy, biopsies should be taken to confirm or rule out the disease.
Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity.
Vaccines (Basel)
February 2024
Immunology Division, The Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.
Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal vaccination strategy. In this study, the immune effects of hyposplenism in CD, and the accuracy of screening approaches and protective responses induced by two different pneumococcal vaccines were examined.
View Article and Find Full Text PDFVaccination Status and Attitudes towards Vaccines in a Cohort of Patients with Celiac Disease.
Vaccines (Basel)
July 2022
Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Article Synopsis
- A study aimed to investigate celiac disease (CD) patients' vaccination status and attitudes towards vaccines, highlighting the lack of prior research on this topic.
- An anonymous online questionnaire was distributed to CD patients, analyzing self-reported vaccination history and attitudes, which ranged from positive to negative, while assessing various influencing factors.
- Results showed that 80% of respondents had a positive attitude towards vaccines; however, vaccination rates for certain diseases remained low, especially those related to complications from CD, indicating a gap in healthcare awareness and preventative measures.
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