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Medication Hazards and Outcome Patterns of Pediatric Drug-Associated Liver Injury in Taiwan: An Analysis of 1998-2017 Spontaneous Adverse Drug Reaction Reports.
Drugs Real World Outcomes
January 2025
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 100025, Taiwan.
Background And Objectives: Accumulating pediatric efficacy and safety data on drug use is inherently challenging yet essential. This study aimed to analyze the frequency and compute the odds of pediatric drug-associated liver injury across age groups (early childhood, middle childhood, and adolescence) and therapeutic categories using adverse drug reactions (ADRs) reporting data spanning nearly two decades.
Methods: We analyzed the reports of suspected ADRs occurring in children and adolescents in the Taiwan National Adverse Drug Reaction Reporting System during the period from May 1998 until July 2017.
Heterozygous missense mutation of the fibrinogen gene associated with cryptogenic liver disease in a 15-months-old Canadian caucasian child.
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Anatomical Pathology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Hepatic fibrinogen storage disease is an uncommon autosomal dominant hereditary illness marked by hypofibrinogenemia and the accumulation of variant fibrinogen in the hepatic endoplasmic reticulum. We present an asymptomatic 15-month-old male with elevated liver enzymes. Test results indicate hypofibrinogenemia.
View Article and Find Full Text PDFHepatic Mesenchymal Hamartoma With Elevated Alpha-Fetoprotein: A Diagnostic Dilemma.
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Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Hepatic mesenchymal hamartoma (HMH) is an uncommon, benign liver tumor predominantly affecting children under three years of age. It is characterized histologically by disorganized mesenchymal stroma, abnormal bile ducts, blood vessels, and hepatocytes. HMH can present as a large cystic mass, a solid mass, or a combination of both.
View Article and Find Full Text PDFCavo-Atrial Inferior Vena Cava (IVC) Restoration With Polytetrafluoroethylene Graft: Overcoming Lethal Injuries.
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Hepato-Pancreato-Biliary Surgery and Liver Transplantation, London Bridge Hospital, London, GBR.
Injuries to the inferior vena cava (IVC) carry high risks and mortality rates. We present a case of suprahepatic IVC injury that was successfully treated with polytetrafluoroethylene (PTFE) graft insertion without cardiopulmonary bypass. A 46-year-old woman was transferred to our trauma centre after a high-speed motor vehicle collision.
View Article and Find Full Text PDFMacro-vacuolar steatosis in a cirrhotic liver mimicking metastatic disease.
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Radiology Unit, "Papardo" Hospital, Messina, ME 98158, Italy.
Multinodular steatosis represents a relatively uncommon manifestation of fatty liver disease (FLD). Co-morbidities such as metabolic syndrome or cirrhosis are often associated. Despite typical features of imaging (ultrasound, CT, and MRI), core biopsy sometimes remains the gold standard for diagnosis.
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