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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport.
Stem Cell Res Ther
January 2025
College & Hospital of Stomatology, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to elucidate how NEAT1 regulates mitotic proteins during BMSCs aging.
View Article and Find Full Text PDFProteinaceous corals reveal heterogeneity in shifting Southern California oceanographic regimes.
Mar Environ Res
January 2025
Channel Islands National Marine Sanctuary, United States.
The Southern California Bight is an ecologically important region for many local and migratory fauna. We combine bulk and compound-specific amino acid stable isotope measurements in the skeletons of proteinaceous octocorals with new regional ocean modeling system model output to explore biogeochemical changes at two locations within the Bight - Santa Cruz Basin and Santa Barbara Channel. Separated by the Channel Islands, these sites display distinct oceanographic regimes.
View Article and Find Full Text PDFAbnormal cardiovascular control during exercise: Role of insulin resistance in the brain.
Auton Neurosci
January 2025
Departments of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
During exercise circulatory adjustments to meet oxygen demands are mediated by multiple autonomic mechanisms, the skeletal muscle exercise pressor reflex (EPR), the baroreflex (BR), and by feedforward signals from central command neurons in higher brain centers. Insulin resistance in peripheral tissues includes sensitization of skeletal muscle afferents by hyperinsulinemia which is in part responsible for the abnormally heightened EPR function observed in diabetic animal models and patients. However, the role of insulin signaling within the central nervous system (CNS) is receiving increased attention as a potential therapeutic intervention in diseases with underlying insulin resistance.
View Article and Find Full Text PDFComparative analysis of spinal flexion angles during smartphone use in toilet: a randomized cross-over with three-period study.
Acta Bioeng Biomech
June 2024
1Department of Rehabilitation Medicine, Southern Medical University Nanfang Hospital, Guangzhou, China.
: The purpose of this study was to quantify the impact of smartphone use while sitting on the toilet on the spinal flexion angles and the time effect. : Measurements of the spinal flexion angles in the sagittal plane were made by thirty participants while they sat on the toilet for 10 min, using a smartphone in either one, both, or neither hand. The individual's forehead, cervical, thoracic and lumbar spinal areas were each fitted with five different inertial motion sensors.
View Article and Find Full Text PDFChange of the anterior talus-fibular ligament length of asymptomatic patients during inversion stress test.
Wiad Lek
January 2025
MUNICIPAL NONPROFIT ENTERPRISE «TERNOPIL REGIONAL CLINICAL HOSPITAL», TERNOPIL REGIONAL RADA, TERNOPIL, UKRAINE.
Objective: Aim: To study the ATFL length among asymptomatic population of young patients on both joints by using the method of ultrasound examination of the ankle joint and applying the inversion stress test.
Patients And Methods: Materials and Methods: the length of the ATFL was measured among 60 boys and 60 girls during the research. Sonography was performed on both joints, in each of the two studied positions, three times per position in order to obtain the average ligament length.
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