AI Article Synopsis
- - The report introduces a new method for 1,4-conjugate addition using photoredox catalysis, allowing acetic acids to react with electron-deficient olefins to form carbon-carbon (C-C) bonds.
- - This reaction occurs under mild conditions using visible light, making it an efficient process for synthesizing complex structures.
- - The method is particularly useful for creating biologically relevant, functionalized small molecules like drug candidates from weakly nucleophilic heterocycles, including indoles and imidazoles.
Article Abstract
In this report, we describe a new photoredox catalyzed 1,4-conjugate addition of -substituted acetic acids to electron-deficient olefins via decarboxylative C-C bond formation. This C-C bond formation occurred under mild conditions enabled by visible light irradiation. This transformation facilitated the synthesis of biologically relevant -substituted heterocyclic structural motifs not readily accessible by other methods. The C-C bond formation protocol was applied to weakly nucleophilic heterocycles such as indoles, indazoles, imidazoles, and cyclic amides to form functionalized drug-like small molecule.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.0c00873 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!