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Purpose: The NCI-MATCH trial assigned patients with solid tumors, lymphomas, or multiple myeloma to targeted therapies on the basis of identified genetic alterations from tumor biopsies. In preclinical models, ()-inactivated tumors display sensitivity to focal adhesion kinase (FAK) inhibition. The EAY131-U subprotocol evaluated the efficacy of defactinib, a FAK inhibitor, in patients with -altered tumors.
View Article and Find Full Text PDFNeonatal Hyperbilirubinemia: A Case of Complex Management Involving ABO Incompatibility, Sepsis, and Suspected G6PD Deficiency treated with Methyl Prednisolone.
Niger Med J
November 2024
Department of Paediatrics, Abubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria.
Article Synopsis
- * A case study involved a 22-hour-old neonate with severe hyperbilirubinemia due to ABO incompatibility, where traditional treatments were ineffective, leading to the off-label use of low-dose intravenous methylprednisolone, which improved the condition rapidly.
- * Managing severe NNJ poses challenges, especially in resource-limited settings, highlighting the need for further research on immunomodulatory treatments like methylprednisolone to assess their safety and effectiveness.
Meta-analysis of the efficacy of different blue light therapy methods for neonatal jaundice.
J Matern Fetal Neonatal Med
December 2025
Department of Neonatology, Wenzhou People's Hospital, Wenzhou, China.
Objective: To analyze and evaluate the efficacy of different blue light therapy methods and provide evidence-based recommendations for their selection in clinical practice.
Methods: Clinical randomized controlled trials (RCTs) evaluating the efficacy of various blue light therapy methods for neonatal jaundice were retrieved from both domestic and international databases. The search period covered the inception of each database until November 2023.
Treatment Response and Survival with Chemotherapy for Unresectable, Nonmetastatic Cholangiocarcinoma.
Euroasian J Hepatogastroenterol
January 2024
Department of Medical Oncology, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.
Background And Objectives: Limited studies have dwelt upon the treatment of unresectable, nonmetastatic cholangiocarcinoma as a separate entity. Hence, the management protocols are not clearly defined for this subgroup of patients. We aimed to analyze patients treated for unresectable, nonmetastatic cholangiocarcinoma.
View Article and Find Full Text PDFAsplenia-Associated Babesiosis: A Quagmire Traversed by Exchange Transfusion.
J Med Cases
July 2024
Department of Internal Medicine, Tower Health, Reading Hospital, West Reading, PA, USA.
Babesiosis is a potentially life-threatening tick-borne parasitic infection. Severe disease in splenectomized individuals may require exchange transfusion. A 58-year-old male with a history of splenectomy presented with 2 weeks of subjective fever, weakness, and abdominal pain.
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