The article is devoted to the study of the circumstances of life, illness and creativity of the famous composer Modest Mussorgsky in aspects of possible influence of alcohol intake. For the purpose of retrospective diagnosis of alcohol dependence, and also for assessing the possibility of its impact on the composer's creativity, a pathographic analysis of publications about Modest Mussorgsky health throughout his life was carried out. A study of the letters of M.P. Mussorgsky, the memoirs of his contemporaries, the works of the composer's biographers, as well as the analytical studies of specialists in retrospective diagnostics showed that alcohol dependence negatively affected his creative activity. However, despite the progressive, clearly malignant course of alcohol dependence, the composer's professional skills evolved until the last days of his life. It is no less significant that in the most unfavorable periods of life, the composer wrote his most significant works. Often, Mussorgsky's music in its positive emotional content contrasts sharply with the grim realities of his life. There is no doubt that the composer's work was his only effective means of combating both alcohol addiction and life's hardships.
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http://dx.doi.org/10.17116/jnevro202012002166 | DOI Listing |
J Phys Chem A
January 2025
Institute of Physical Chemistry, University of Göttingen, Tammannstrasse 6, 37077 Göttingen, Germany.
The persistent organic radical 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO) protects its NO radical center by four methyl groups. Two of them are arranged tightly (t) on one side of the six-membered puckered heterocycle, and the other two more openly (o) on the other side. It is shown by OH stretching infrared spectroscopy in heated supersonic jet expansions that the hydrogen bond and aromatic ring of a first solvating benzyl alcohol have almost no preference for either side.
View Article and Find Full Text PDFScand J Prim Health Care
January 2025
Primary Health Care Centre Ekholmen, Linköping and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Background And Aims: Alcohol use disorder (AUD) and hazardous alcohol use are common but underdiagnosed in primary health care (PHC). This study aimed to explore general practitioners' (GPs') experiences and perceptions of using B-Phosphatidylethanol (PEth), a specific quantitative biomarker for alcohol use, in their clinical work with patient consultations and treatment follow-up in Swedish PHC.
Design, Participants, And Setting: Individual interviews were conducted with GPs and resident GPs (n 20) in Swedish PHC and analysed using qualitative content analysis.
Mol Psychiatry
January 2025
Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.
The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has been linked to sleep regulation, feeding and motivation for salient rewards including drugs of abuse. However, relatively little has been done to examine genes associated with orexin signaling and specific behavioral phenotypes in humans. Here, we tested for association of twenty-seven genes involved in orexin signaling with behavioral phenotypes in humans.
View Article and Find Full Text PDFInt J Pharm
January 2025
Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006 China. Electronic address:
Disulfiram (DSF), which has been traditionally used to treat alcoholism, has been shown to inhibit tumor growth, indicating its potential as an anticancer agent. However, its development and application are hindered by its poor water solubility, instability in physiological environments, and low bioavailability. In this study, phenylboronic acid-chitosan (PBA-CS) grafts were synthesized using the carbodiimide method.
View Article and Find Full Text PDFCien Saude Colet
January 2025
Instituto René Rachou, Fundação Oswaldo Cruz (Fiocruz Minas). Av. Augusto de Lima 1715, Barro Preto. 30190-002 Belo Horizonte MG Brasil.
This integrative review systematized the factors that influence access to mental health services for the Homeless Population (HP) in harmful use of alcohol and other drugs in the Psychosocial Care Network (RAPS) in Brazil by categorizing the factors into access "barriers" and "facilitators". We selected 13 corresponding articles and subsequently assessed their methodological quality. We identified 19 access barriers and 22 access facilitators, observing a convergence and complementarity of the factors identified, with no disagreements between authors.
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