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http://dx.doi.org/10.1016/S1473-3099(20)30297-8DOI Listing

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BackgroundEarly detection and characterisation of SARS-CoV-2 variants have been and continue to be essential for assessing their public health impact. In August 2023, Santé publique France implemented enhanced surveillance for BA.2.

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Background: Despite declining COVID-19 incidence, healthcare workers (HCWs) still face an elevated risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. We developed a diagnostic multivariate model to predict positive reverse transcription polymerase chain reaction (RT-PCR) results in HCWs with suspected SARS-CoV-2 infection.

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The COVID-19 pandemic has caused substantial worldwide disruptions in health, economy, and society, manifesting symptoms such as loss of smell (anosmia) and loss of taste (ageusia), that can result in prolonged sensory impairment. Establishing the host genetic etiology of anosmia and ageusia in COVID-19 will aid in the overall understanding of the sensorineural aspect of the disease and contribute to possible treatments or cures. By using human genome sequencing data from the University of Iowa (UI) COVID-19 cohort (N=187) and the National Institute of Health All of Us (AoU) Research Program COVID-19 cohort (N=947), we investigated the genetics of anosmia and/or ageusia by employing feature selection techniques to construct a novel variant and gene prioritization pipeline, utilizing machine learning methods for the classification of patients.

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Olfactory dysfunction in COVID-19; Self-report or olfactory dysfunction test?

Caspian J Intern Med

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Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Article Synopsis
  • - Researchers examined the differences between self-reported smell disorders and those identified through specific tests in COVID-19 patients, reviewing 554 studies from late 2019 to 2020 using systematic methods to categorize findings.
  • - Out of the analyzed studies, 80% relied on patient self-reports regarding olfactory dysfunction, while only 20% utilized specific tests; the results showed a broad range of prevalence in self-reported cases (20%-97%) compared to a much higher incidence of anosmia (65%-98%) in those tested.
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