Segmental vitiligo (SV) is considered to be relatively less responsive form of vitiligo to medical treatment. While excimer light (EL) has shown great promise in treating localized vitiligo especially on face and neck, its efficacy in SV is not reported so commonly. We conducted a retrospective study on patients of childhood SV who had received EL therapy from January 2016 to December 2018 at our institute. Data of all such cases who had received at least 10 doses of EL treatment or achieved complete repigmentation were selected for analysis. Records of 26 children with SV satisfied the selection criteria. Excellent response (>75% repigmentation) was documented in 65.4% (17/26) patients with 7.7% (2/26) patients showing partial (50%-75%) repigmentation. Response to treatment was seen to correlate inversely with the duration of SV. Patients with SV of <6 months reported better results with all 10 cases achieving complete or near complete (>75%) repigmentation. In contrast, only 44% patients (7/16) with disease duration of >6 months were seen to have achieved >75% repigmentation.
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http://dx.doi.org/10.1111/dth.13408 | DOI Listing |
Environ Sci Technol
January 2025
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Emerging mercury-free ultraviolet (UV) sources, such as krypton chloride excimer (KrCl*) lamps and UV light emitting diodes (UV-LEDs), emit diverse wavelengths with distinct inactivation mechanisms. The combined application has the potential to improve disinfection effectiveness through synergism. In this study, a mini-fluidic photoreaction system equipped with a KrCl* lamp (222 nm) and a strip of UV-LEDs (275 nm) was developed, which could individually/simultaneously deliver accurate UV radiation(s) at 222 nm (0.
View Article and Find Full Text PDFProg Retin Eye Res
December 2024
ELZA Institute, Webereistrasse 2, CH-8953, Dietikon, Switzerland; Laboratory for Ocular Cell Biology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206, Geneva, Switzerland. Electronic address:
First introduced over 20 years ago as a treatment for progressive keratoconus, the original "Dresden" corneal cross-linking (CXL) protocol involved riboflavin saturation of the stroma, followed by 30 min of 3 mW/cm-intensity ultraviolet-A (UV-A) irradiation. This procedure generates reactive oxygen species (ROS) that cross-link stromal molecules, thereby stiffening the cornea and counteracting the ectasia-induced weakening. Due to their large size, riboflavin molecules cannot readily pass through the corneal epithelial cell tight junctions; thus, epithelial debridement was performed.
View Article and Find Full Text PDFDermatol Online J
October 2024
The Ronald O Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
All types of alopecia, including androgenetic alopecia, alopecia areata, and lichen planopilaris/frontal fibrosing alopecia, affect over half of men and women. Though a common dermatological experience, many patients with visible hair loss report significant psychological and social distress and, consequently seek treatment. Current existing therapeutic regimens have proven to be efficacious, though may result in various adverse effects and require lifelong use.
View Article and Find Full Text PDFJ Cosmet Dermatol
December 2024
Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: A 308 nm excimer light is an effective treatment for vitiligo, with fewer treatment times, rapid obvious effects, relatively complete pigment recovery, good patient compliance, and safe and effective treatment for children. The disadvantage of this treatment is that some patients have a plateau during which the skin lesion reduction rate slows down or stalls after multiple treatments.
Methods: Treatment data were collected from all vitiligo patients in the Dermatology Department, distinguishing between those who underwent 308 nm excimer light treatment alone and those who received a combination of 308 nm excimer light and 2940 erbium laser treatment.
J Dermatol
December 2024
Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Narrow-band UVB (NB-UVB) therapy at a wavelength of 311 nm is often used to treat mycosis fungoides (MF). However, we occasionally encounter cases of erythema induced by low doses of NB-UVB, known as an abnormal light reaction (ALR). We investigated the incidence of ALR in patients with MF and the association between ALR and clinical and laboratory findings.
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