AI Article Synopsis
- The recent discovery of SARS-CoV-2 as the virus causing COVID-19 prompted research comparing its effects to those of earlier coronaviruses like SARS-CoV and MERS-CoV.
- In experiments with cynomolgus macaques, SARS-CoV-2 was found in the respiratory tract without noticeable symptoms, but caused lung damage similar to COVID-19.
- The findings indicate that SARS-CoV-2 can induce a disease comparable to COVID-19 in macaques and offer a valuable model for testing vaccines and treatments.
Article Abstract
The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164679 | PMC |
| http://dx.doi.org/10.1126/science.abb7314 | DOI Listing |
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